(LYS22)-AMYLOID B-PROTEIN (1-40). 0.5mg The Italian mutation of +-amyloid 1-40 (E22K) aggregates mor ...
(LYS22)-AMYLOID B-PROTEIN (1-40). 0.5mg The Italian mutation of +-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys-- and Asp-- in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type A+ by neprilysin. CAS: 302905-01-7 C195H300N54O56S FW: 4328.92 . Synonym: Amyloid b-Protein (1-40) Italian Mutation, Amyloid b-Protein (1-40) E22K Read more
