PACAP-38 (HUMAN, MOUSE, OVINE) 1mg Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) an ...
PACAP-38 (HUMAN, MOUSE, OVINE) 1mg Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of +-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of A+40/42, and thus may help to prevent AlzheimerGs disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the A+-degrading enzyme neprilysin via induction of somatostatin. CAS: 124123-15-5 C203H331N63O53S FW: 4534.32. Synonym: Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat). Read more
