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GRF (1-29) AMIDE (HUMAN). 5mg GRF (1-29) amide (sermorelin) is the shortest GRF fragment with full biological activity. CAS: 86168-78-7 C149H246N44O42S FW: 3357.93 . Synonym: Sermorelin

(D-TRP6)-LHRH. 25mg LHRH agonist used in the treatment of prostate cancer. Triptorelin decreases the secretion of LH and FSH. CAS: 57773-63-4 C64H82N18O13 FW: 1311.47 . Synonym: Triptorelin, (D-Trp6)-GnRH

(DES-GLY10,D-TRP6,PRO-NHET9)-LHRH, 5mg Short-term administration of deslorelin stimulates the formation of LH and FSH, which induce an increase in the production of testosterone and estradiol. Prolonged administration of the GnRH agonist causes a sustained down-regulation of circulating LH and FSH levels and hence suppression of steroidogenesis. CAS: 57773-65-6 C64H83N17O12 FW: 1282.47. Synonym: Deslorelin High acetate salt.

(DES-GLY10,D-TRP6,PRO-NHET9)-LHRH, 25mg Short-term administration of deslorelin stimulates the formation of LH and FSH, which induce an increase in the production of testosterone and estradiol. Prolonged administration of the GnRH agonist causes a sustained down-regulation of circulating LH and FSH levels and hence suppression of steroidogenesis. CAS: 57773-65-6 C64H83N17O12 FW: 1282.47. Synonym: Deslorelin High acetate salt.

(DES-GLY10,D-SER(TBU)6,PRO-NHET9)- 25mg Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH. CAS: 57982-77-1 C60H86N16O13 FW: 1239.44. Synonym: Buserelin.

PTH (1-34) (HUMAN). 1mg This peptide consisting of the N-terminal 34 amino acid residues of pTH shows the same potency and pharmacological profile as the native hormone. Administration of teriparatide stimulates bone formation and increases the bone mineral density (BMD). CAS: 52232-67-4 C181H291N55O51S2 FW: 4117.77 . Synonym: Teriparatide

PTH (1-34) (HUMAN). 5mg This peptide consisting of the N-terminal 34 amino acid residues of pTH shows the same potency and pharmacological profile as the native hormone. Administration of teriparatide stimulates bone formation and increases the bone mineral density (BMD). CAS: 52232-67-4 C181H291N55O51S2 FW: 4117.77 . Synonym: Teriparatide

GLP-1 (7-37) (HUMAN, BOVINE, GUINEA) 1mg CAS: 106612-94-6 C151H228N40O47 FW: 3355.71. Synonym: Insulinotropin (human, bovine, guinea pig, mouse, rat), Glucagon-Like Peptide 1 (7-37) (human, bovine, guinea pig, mouse, rat), Preproglucagon (98-128) (human, bovine, guinea pig, mouse, rat), Proglucagon (78-108) (human, bovine, guinea pig, mouse, rat).

GLP-1 (7-37) (HUMAN, BOVINE, GUINEA) 5mg CAS: 106612-94-6 C151H228N40O47 FW: 3355.71. Synonym: Insulinotropin (human, bovine, guinea pig, mouse, rat), Glucagon-Like Peptide 1 (7-37) (human, bovine, guinea pig, mouse, rat), Preproglucagon (98-128) (human, bovine, guinea pig, mouse, rat), Proglucagon (78-108) (human, bovine, guinea pig, mouse, rat).

Ovalbumin (323-339) (chicken, japanese quail) 5mg. Ovalbumin (323-339) (chicken, japanese quail) H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH 5mg, Synonym: OVA (323-339), Molecular Formula: CGGHGGGNGGOGG, Cas number: 92915-79-2.

(PRO-NHNH29)-BUSERELIN. 1mg Impurity E of the Goserelin Ph. Eur. monograph. CAS: 147688-42-4 C58H83N17O13 FW: 1226.4 . Synonym: (Pro-NHNH29)-Buserelin, Decarbamoylgoserelin, (Des-carboxamide)-Goserelin

(PRO-NHNH29)-BUSERELIN. 5mg Impurity E of the Goserelin Ph. Eur. monograph. CAS: 147688-42-4 C58H83N17O13 FW: 1226.4 . Synonym: (Pro-NHNH29)-Buserelin, Decarbamoylgoserelin, (Des-carboxamide)-Goserelin

KISSPEPTIN-13 (HUMAN). 5mg An LRF-amide motif containing fragment of malignant melanoma metastasis suppressor KiSS-1. It bound with low nanomolar affinity to the rat and human G protein-coupled receptor GPR54 expressed in Chinese hamster ovary K1 cells and stimulated PIP2 hydrolysis, Ca2+ mobilization, arachidonic acid release, ERK1/2 and p38 MAP kinase phosphorylation, and stress fiber formation but inhibited cell proliferation. CAS: 374675-18-0 C78H107N21O18 FW: 1626.84 . Synonym: Malignant Melanoma Metastasis-Suppressor KiSS-1 (109-121) (human), KiSS-1 (109-121) (human), Metastin (42-54) (human), Kisspeptin-14 (2-14) (human), Kisspeptin-54 (42-54) (human)

OXYNTOMODULIN (HUMAN, MOUSE, RAT), 0.5mg Oxyntomodulin potently inhibits gastric acid secretion and pancreatic enzyme secretion when infused iv. Moreover, it was shown that intracerebroventricularly and into the hypothalamic paraventricular nucleus injected oxyntomodulin inhibits food intake in fasted and nonfasted animals potently and in a sustained manner. CAS: 159002-68-3 C192H295N61O60S FW: 4449.9. Synonym: Glucagon-37 (human, mouse, rat), OXM (human, mouse, rat), Preproglucagon (53-89) (human, mouse, rat), Proglucagon (33-69) (human, mouse, rat).

OXYNTOMODULIN (HUMAN, MOUSE, RAT), 1mg Oxyntomodulin potently inhibits gastric acid secretion and pancreatic enzyme secretion when infused iv. Moreover, it was shown that intracerebroventricularly and into the hypothalamic paraventricular nucleus injected oxyntomodulin inhibits food intake in fasted and nonfasted animals potently and in a sustained manner. CAS: 159002-68-3 C192H295N61O60S FW: 4449.9. Synonym: Glucagon-37 (human, mouse, rat), OXM (human, mouse, rat), Preproglucagon (53-89) (human, mouse, rat), Proglucagon (33-69) (human, mouse, rat).

(D-2-NAL6)-LHRH. 1mg Nafarelin is a synthetic decapeptide agonist of the luteinizing hormone-releasing hormone (LHRH) which is approximately 200 times more potent than the natural peptide. Like LHRH nafarelin stimulates the release of the gonadotrophins luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary which in turn results in an initial increase of testosterone and estradiol synthesis. Continuous administration of LHRH or one of its analogs causes a sustained down-regulation of circulating LH and FSH levels leading to a suppression of testicular and ovarian steroidogenesis. Currently, nafarelin is indicated for the treatment of endometriosis and for the use in reproductive medicine. CAS: 76932-56-4 C66H83N17O13 FW: 1322.49 . Synonym: Nafareli....

(D-2-NAL6)-LHRH. 5mg Nafarelin is a synthetic decapeptide agonist of the luteinizing hormone-releasing hormone (LHRH) which is approximately 200 times more potent than the natural peptide. Like LHRH nafarelin stimulates the release of the gonadotrophins luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary which in turn results in an initial increase of testosterone and estradiol synthesis. Continuous administration of LHRH or one of its analogs causes a sustained down-regulation of circulating LH and FSH levels leading to a suppression of testicular and ovarian steroidogenesis. Currently, nafarelin is indicated for the treatment of endometriosis and for the use in reproductive medicine. CAS: 76932-56-4 C66H83N17O13 FW: 1322.49 . Synonym: Nafarelin

(GLY22)-AMYLOID B-PROTEIN (1-42). 0.5mg The arctic mutant of amyloid +-protein 1-42, in which Glu-- is substituted by Gly, is distinctly more amyloidogenic than the wild-type A+ 1-42. C200H307N55O58S FW: 4442.04 . Synonym: Amyloid b-Protein (1-42) Arctic Mutation, Amyloid b-Protein (1-42) E22G

(GLY22)-AMYLOID B-PROTEIN (1-42). 1mg The arctic mutant of amyloid +-protein 1-42, in which Glu-- is substituted by Gly, is distinctly more amyloidogenic than the wild-type A+ 1-42. C200H307N55O58S FW: 4442.04 . Synonym: Amyloid b-Protein (1-42) Arctic Mutation, Amyloid b-Protein (1-42) E22G

RETROCYCLIN-1. 0.5mg The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors. (Disulfide bonds between Cys3 and Cys16/Cys5 and Cys14/Cys7 and Cys12) CAS: 724760-19-4 C74H128N30O18S6 FW: 1918.42 ....

RETROCYCLIN-1. 1mg The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors. (Disulfide bonds between Cys3 and Cys16/Cys5 and Cys14/Cys7 and Cys12) CAS: 724760-19-4 C74H128N30O18S6 FW: 1918.42 .....

AC-LPFFD-NH2. 5mg Ac-LPFFD-NH2 is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It acts as a +-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimers disease (AD) models is additionally reported for this pentapeptide. CAS: 339990-02-2 C35H46N6O8 FW: 678.79 . Synonym: Ac-LPFFD-NH2

AC-LPFFD-NH2. 25mg Ac-LPFFD-NH2 is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It acts as a +-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimers disease (AD) models is additionally reported for this pentapeptide. CAS: 339990-02-2 C35H46N6O8 FW: 678.79 . Synonym: Ac-LPFFD-NH2

(D-SER4)-LEUPROLIDE. 1mg Impurity A of the Leuprorelin Ph. Eur. monograph. CAS: 62621-13-0 C59H84N16O12 FW: 1209.42 . Synonym: (D-Ser4)-Leuprolide, (D-Ser4)-Leuprorelin

(D-SER4)-LEUPROLIDE. 5mg Impurity A of the Leuprorelin Ph. Eur. monograph. CAS: 62621-13-0 C59H84N16O12 FW: 1209.42 . Synonym: (D-Ser4)-Leuprolide, (D-Ser4)-Leuprorelin

(SER(AC)4)-LEUPROLIDE. 1mg Impurity D of the Leuprorelin Ph. Eur. monograph. C61H86N16O13 FW: 1251.45 . Synonym: (Ser(Ac)4)-Leuprolide, (Ser(Ac)4)-Leuprorelin

(SER(AC)4)-LEUPROLIDE. 5mg Impurity D of the Leuprorelin Ph. Eur. monograph. C61H86N16O13 FW: 1251.45 . Synonym: (Ser(Ac)4)-Leuprolide, (Ser(Ac)4)-Leuprorelin

GALANIN-LIKE PEPTIDE (RAT). 0.5mg Galanin-like peptide (GALP), first isolated from the porcine hypothalamus and subsequently also identified in rats and humans, is a 60 amino acid neuropeptide that unlike galanin, has a non-amidated C-terminus. Its amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) fragment of galanin. In contrast to galanin which is relatively non-selective, receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2) and a lower affinity for the GALR1 receptor. Furthermore, it could be demonstrated that GALP stimulates food intake with a ten fold higher orexigenic activity than galanin and may also affect emotional state in the CNS. CAS: 245114-97-0 C288H461N87O83S FW: 6502.43 . Synonym: GALP (r....

GALANIN-LIKE PEPTIDE (RAT). 1mg Galanin-like peptide (GALP), first isolated from the porcine hypothalamus and subsequently also identified in rats and humans, is a 60 amino acid neuropeptide that unlike galanin, has a non-amidated C-terminus. Its amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) fragment of galanin. In contrast to galanin which is relatively non-selective, receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2) and a lower affinity for the GALR1 receptor. Furthermore, it could be demonstrated that GALP stimulates food intake with a ten fold higher orexigenic activity than galanin and may also affect emotional state in the CNS. CAS: 245114-97-0 C288H461N87O83S FW: 6502.43 . Synonym: GALP (ra....

LHRH (1-5) (FREE ACID). 5mg According to Wu et al., this metabolite of GnRH could be involved in the regulation of the synthesis, secretion, and functions of the native hormone. CAS: 52434-75-0 C34H38N8O9 FW: 702.72 . LHRH

LHRH (1-5) (FREE ACID). 25mg According to Wu et al., this metabolite of GnRH could be involved in the regulation of the synthesis, secretion, and functions of the native hormone. CAS: 52434-75-0 C34H38N8O9 FW: 702.72 . LHRH

LL-37 AMIDE. 1mg LL-37 amide is an antimicrobial peptide with angiogenic activity. CAS: 597562-32-8 C205H341N61O52 FW: 4492.34 . Synonym: Antibacterial Protein LL-37 amide (human), LL37, CAMP

LL-37 AMIDE. 5mg LL-37 amide is an antimicrobial peptide with angiogenic activity. CAS: 597562-32-8 C205H341N61O52 FW: 4492.34 . Synonym: Antibacterial Protein LL-37 amide (human), LL37, CAMP

NEUROMEDIN S (HUMAN). 0.5mg The 36-amino acid neuropeptide, neuromedin S (NMS), was originally isolated from rat brain as an endogenous ligand for two orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, which have been identified as neuromedin U (NMU) receptors. NMS is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. It has been shown that NMS is implicated in the regulation of circadian rhythms throug h autocrine and/or paracrine actions. C173H265N53O44 FW: 3791.34 . Synonym: NMS (human)

NEUROMEDIN S (HUMAN). 1mg The 36-amino acid neuropeptide, neuromedin S (NMS), was originally isolated from rat brain as an endogenous ligand for two orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, which have been identified as neuromedin U (NMU) receptors. NMS is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. It has been shown that NMS is implicated in the regulation of circadian rhythms throug h autocrine and/or paracrine actions. C173H265N53O44 FW: 3791.34 . Synonym: NMS (human)

UROCORTIN II (MOUSE). 0.5mg Urocortin II (mouse) exhibited considerably higher affinity for both splice variants of the type 2 CRF receptor (CRF-R2) than for CRF-R1. The potencies of Ucn II (mouse) in activating CRF-R2+ and CRF-R2+ were nearly equivalent to that of urocortin (rat). CAS: 330648-32-3 C187H320N56O50 FW: 4152.95 . Synonym: Ucn II (mouse)

UROCORTIN II (MOUSE). 1mg Urocortin II (mouse) exhibited considerably higher affinity for both splice variants of the type 2 CRF receptor (CRF-R2) than for CRF-R1. The potencies of Ucn II (mouse) in activating CRF-R2+ and CRF-R2+ were nearly equivalent to that of urocortin (rat). CAS: 330648-32-3 C187H320N56O50 FW: 4152.95 . Synonym: Ucn II (mouse)

BIOTINYL-SOMATOSTATIN-14. 0.5mg (Disulfide bond) CAS: 145251-83-8 C86H118N20O21S3 FW: 1864.2 . Synonym: Biotinyl-SRIF

BIOTINYL-SOMATOSTATIN-14. 1mg (Disulfide bond) CAS: 145251-83-8 C86H118N20O21S3 FW: 1864.2 . Synonym: Biotinyl-SRIF

(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE . 5mg 2-(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat) is a potent and selective PAR-2 agonist. In cultured human PAR-2-expressing cells H-6246 was equally effective as SLIGRLamide (H-5078), in rat PAR-2-expressing cells it was 10 to 25 times more potent than SLIGRLamide in increasing intracellular calcium levels. In bioassays of tissue PAR-2 activity, measured as arterial vasodilation and hyperpolarization this agonist was 10 to 300 times more potent than H-5078. CAS: 729589-58-6 C36H63N11O8 FW: 777.97 . Synonym: (2-Furoyl)-LIGRLOamide

(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE . 25mg 2-(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat) is a potent and selective PAR-2 agonist. In cultured human PAR-2-expressing cells H-6246 was equally effective as SLIGRLamide (H-5078), in rat PAR-2-expressing cells it was 10 to 25 times more potent than SLIGRLamide in increasing intracellular calcium levels. In bioassays of tissue PAR-2 activity, measured as arterial vasodilation and hyperpolarization this agonist was 10 to 300 times more potent than H-5078. CAS: 729589-58-6 C36H63N11O8 FW: 777.97 . Synonym: (2-Furoyl)-LIGRLOamide

ENTEROTOXIN STP (E. COLI). 0.5mg Enterotoxigenic E.coli are able to produce several toxic peptides which may cause acute diarrhea in humans and domestic animals. The E.coli heat-stable enterotoxin STp is syntheszied in vivo as a 72 amino acid precursor consisting of pre-, pro-, and mature region. Mature STp is composed of 18 amino acids containing three intramolecular disulfide bonds, which seem to be important for the correct conformation of the biologically active structure. (Disulfide bonds between Cys5 and Cys10/Cys6 and Cys14/Cys9 and Cys17) CAS: 115474-04-9 C81H110N20O26S6 FW: 1972.28 . Synonym: STp (E. coli), Enterotoxin STp Precursor (55-72) (E. coli)

ENTEROTOXIN STP (E. COLI). 1mg Enterotoxigenic E.coli are able to produce several toxic peptides which may cause acute diarrhea in humans and domestic animals. The E.coli heat-stable enterotoxin STp is syntheszied in vivo as a 72 amino acid precursor consisting of pre-, pro-, and mature region. Mature STp is composed of 18 amino acids containing three intramolecular disulfide bonds, which seem to be important for the correct conformation of the biologically active structure. (Disulfide bonds between Cys5 and Cys10/Cys6 and Cys14/Cys9 and Cys17) CAS: 115474-04-9 C81H110N20O26S6 FW: 1972.28 . Synonym: STp (E. coli), Enterotoxin STp Precursor (55-72) (E. coli)

(SAR1,ILE4-+8)-ANGIOTENSIN II, 5mg (Sar-,IleG-+G+)-Angiotensin II activates extracellular signal-regulated kinases 1 and 2 (ERK1/2) via angiotensin II type 1A receptors. Activation is dependent on +-arrestin 2 expression. CAS: 185461-45-4 C43H75N13O9 FW: 918.15. angiotensin.

HIV-1 TAT PROTEIN (47-57). 5mg YGRKKRRQRRR, a cell penetrating peptide derived from the HIV-1 tat protein transduction domain (PTD), has been shown to promote the entry of nucleic acids into several cell types. CAS: 191936-91-1 C64H118N32O14 FW: 1559.85 . HIV-1

HIV-1 TAT PROTEIN (47-57). 25mg YGRKKRRQRRR, a cell penetrating peptide derived from the HIV-1 tat protein transduction domain (PTD), has been shown to promote the entry of nucleic acids into several cell types. CAS: 191936-91-1 C64H118N32O14 FW: 1559.85 . HIV-1

(DES-GLY10,D-LEU6,[13C6]LEU7,PRO-NHET) 0.5mg Heavy isotope-labeled leuprorelin useful for pharmacokinetic/pharmacodynamic studies in combination with Bachem product H-4060 (Leuprolide) or the corresponding generic API. C5313C6H84N16O12 FW: 1215.35. Synonym: ([13C6]Leu7)-Leuprolide.

(DES-GLY10,D-LEU6,[13C6]LEU7,PRO-NHET) 1mg Heavy isotope-labeled leuprorelin useful for pharmacokinetic/pharmacodynamic studies in combination with Bachem product H-4060 (Leuprolide) or the corresponding generic API. C5313C6H84N16O12 FW: 1215.35. Synonym: ([13C6]Leu7)-Leuprolide.

(DES-OCTANOYL)-GHRELIN (MOUSE, RAT) 0.5mg In contrast to the octanoylated peptide, the non-acylated ghrelin does not activate growth hormone secretagogue receptor-expressing cells. The peptide decreases food intake and gastroduodenal motility in conscious rats, probably by crossing the blood-brain barrier and activating the brain receptor directly. CAS: 307950-60-3 C139H231N45O41 FW: 3188.64. ghrelin.

(DES-OCTANOYL)-GHRELIN (MOUSE,RAT) 1mg In contrast to the octanoylated peptide, the non-acylated ghrelin does not activate growth hormone secretagogue receptor-expressing cells. The peptide decreases food intake and gastroduodenal motility in conscious rats, probably by crossing the blood-brain barrier and activating the brain receptor directly. CAS: 307950-60-3 C139H231N45O41 FW: 3188.64. ghrelin.

(D-SER6,AZAGLY10)-LHRH, 1mg CAS: 65807-03-6 C55H76N18O14 FW: 1213.32. Synonym: (D-Ser6)-Goserelin.

(D-SER6,AZAGLY10)-LHRH, 5mg CAS: 65807-03-6 C55H76N18O14 FW: 1213.32. Synonym: (D-Ser6)-Goserelin.

ACETYL-(D-ARG10,CYS11,D-PHE14,CYS17) 1mg Highly potent and selective +-MSH-derived melanocortin-4 receptor (MC-4R) agonist with sub-nanomolar potency. The binding affinities for human MC-4R, MC-1R, MC-3R and MC-5R were 0.55 - 0.06, 16.78 - 1.53, 56.79 - 4.66, and 500 nM, respectively. Daily subcutaneous injection of H-6268 to diet-induced obese rats over a period of 14 days demonstrated an effect on reduction of fat mass. (Disulfide bond) CAS: 819048-44-7 C51H70N18O11S2 FW: 1175.36. MSH.

ACETYL-(D-ARG10,CYS11,D-PHE14,CYS17) 5mg Highly potent and selective +-MSH-derived melanocortin-4 receptor (MC-4R) agonist with sub-nanomolar potency. The binding affinities for human MC-4R, MC-1R, MC-3R and MC-5R were 0.55 - 0.06, 16.78 - 1.53, 56.79 - 4.66, and 500 nM, respectively. Daily subcutaneous injection of H-6268 to diet-induced obese rats over a period of 14 days demonstrated an effect on reduction of fat mass. (Disulfide bond) CAS: 819048-44-7 C51H70N18O11S2 FW: 1175.36. MSH.

TYR-(D-DAB4,ARG5,D-TRP8)-CYCLO-SOMA, 1mg High affinity ligand for all five somatostain receptors (sst1-sst5). In AtT-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (H-1490) and octreotide (H-5972). In a model of epileptogenesis, however, KE 108 did not exhibit antiepileptic activity sug gesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand. CAS: 496849-46-8 C67H85N15O11 FW: 1276.51. Synonym: KE 108.

TYR-(D-DAB4,ARG5,D-TRP8)-CYCLO-SOMA, 5mg High affinity ligand for all five somatostain receptors (sst1-sst5). In AtT-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (H-1490) and octreotide (H-5972). In a model of epileptogenesis, however, KE 108 did not exhibit antiepileptic activity sug gesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand. CAS: 496849-46-8 C67H85N15O11 FW: 1276.51. Synonym: KE 108.

ACETYL-HEME-BINDING PROTEIN 1 (1-21. 1mg F2L is an acetylated peptide corresponding to an N-terminal fragment of the human heme-binding protein. Ac-MLGMIKNSLFGSVETWPWQVL acts specifically throug h the FPR-like receptor (FPRL) 2 promoting calcium mobilization and chemotaxis in dendritic cells and monocytes. In neutrophils, F2L inhibited FPR and FPRL1-mediated signaling. CAS: 946571-77-3 C116H176N26O30S2 FW: 2478.96 . Synonym: F2L

ACETYL-HEME-BINDING PROTEIN 1 (1-21. 5mg F2L is an acetylated peptide corresponding to an N-terminal fragment of the human heme-binding protein. Ac-MLGMIKNSLFGSVETWPWQVL acts specifically throug h the FPR-like receptor (FPRL) 2 promoting calcium mobilization and chemotaxis in dendritic cells and monocytes. In neutrophils, F2L inhibited FPR and FPRL1-mediated signaling. CAS: 946571-77-3 C116H176N26O30S2 FW: 2478.96 . Synonym: F2L

APELIN-17 (HUMAN, BOVINE, MOUSE) 1mg Apelin-17 is an endogenous ligand of the human orphan G protein-coupled receptor APJ, reported to act as a coreceptor of CD4 for human and simian immunodeficiency viruses. Apelin-17 and apelin-13 represent the predominant molecular forms of apelin present in the whole brain, hypothalamus, and plasma. Like apelin-13, apelin-17 exhibited a high activity on extracellular acidification rate and strongly inhibited forskolin-stimulated cAMP production in CHO cells expressing the human or the rat apelin receptor. The peptide might play a crucial role in the maintenance of body fluid homeostasis by counteracting AVP (arginine vasopressin) actions throug h inhibition of AVP neuron activity and AVP release. CAS: 217082-57-0 C96H156N34O20S FW: 2138.58. Synonym: Pr.....

APELIN-17 (HUMAN, BOVINE, MOUSE) 5mg Apelin-17 is an endogenous ligand of the human orphan G protein-coupled receptor APJ, reported to act as a coreceptor of CD4 for human and simian immunodeficiency viruses. Apelin-17 and apelin-13 represent the predominant molecular forms of apelin present in the whole brain, hypothalamus, and plasma. Like apelin-13, apelin-17 exhibited a high activity on extracellular acidification rate and strongly inhibited forskolin-stimulated cAMP production in CHO cells expressing the human or the rat apelin receptor. The peptide might play a crucial role in the maintenance of body fluid homeostasis by counteracting AVP (arginine vasopressin) actions throug h inhibition of AVP neuron activity and AVP release. CAS: 217082-57-0 C96H156N34O20S FW: 2138.58. Synonym: Pr.....

(ALA13)-APELIN-13 (HUMAN BOVINE, 1mg. Specific anatagonist of Apelin-13 (human, bovine, mouse, rat) (H-4566). Systemic administration of (Ala13)-Apelin-13 (human, bovine, mouse, rat) (30 -g/kg) abolished the blood pressure-lowering effects of H-4566 (15 -g/kg) in hypertensive rats. CAS: 568565-11-7 C63H107N23O16S FW: 1474.75. apelin.

(ALA13)-APELIN-13 (HUMAN BOVINE, 5mg. Specific anatagonist of Apelin-13 (human, bovine, mouse, rat) (H-4566). Systemic administration of (Ala13)-Apelin-13 (human, bovine, mouse, rat) (30 -g/kg) abolished the blood pressure-lowering effects of H-4566 (15 -g/kg) in hypertensive rats. CAS: 568565-11-7 C63H107N23O16S FW: 1474.75. apelin.

BIOTINYL-BNP-32 (HUMAN). 0.5mg (Disulfide bond) C153H258N52O44S5 FW: 3690.39 . Synonym: Biotinyl-Brain Natriuretic Peptide-32 (human), Biotinyl-Nesiritide

BIOTINYL-BNP-32 (HUMAN). 1mg (Disulfide bond) C153H258N52O44S5 FW: 3690.39 . Synonym: Biotinyl-Brain Natriuretic Peptide-32 (human), Biotinyl-Nesiritide

FITC-B-ALA-AMYLOID B-PROTEIN 1-40. 0.5mg C218H311N55O64S2 FW: 4790.33 . amyloid

FITC-B-ALA-AMYLOID B-PROTEIN 1-40. 1mg C218H311N55O64S2 FW: 4790.33 . amyloid

GHRELIN-CYS(BMCC-BIOTINYL) (HUMAN. 0.5mg Useful for ELISA development and receptor studies. Active region left intact. C178H293N53O48S2 FW: 4007.74 . Synonym: Ghrelin-Cys(1-biotinamido-4-(4'-maleimido-N-methyl-cyclohexyl)carboxamido)butane) (human)

OBESTATIN (HUMAN). 1mg CAS: 1081110-72-6 C116H176N32O33 FW: 2546.87 . obestatin

(PYR11)-AMYLOID B-PROTEIN (11-40). 0.5mg pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid +-protein (A+) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid +-protein alloforms it could be observed that among these peptides (Pyr--)-amyloid +-protein (11-40) exhibited the greatest retardation of fibrillization rate. CAS: 192377-94-9 C143H226N38O39S FW: 3133.67 . amyloid

(PYR11)-AMYLOID B-PROTEIN (11-40). 1mg pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid +-protein (A+) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid +-protein alloforms it could be observed that among these peptides (Pyr--)-amyloid +-protein (11-40) exhibited the greatest retardation of fibrillization rate. CAS: 192377-94-9 C143H226N38O39S FW: 3133.67 . amyloid

CYS-GLY-LYS-ARG-AMYLOID BETA-PROT. 0.5mg C220H343N63O64S2 FW: 4958.66 . Synonym: (Cys668,Gly669,Arg671)-Amyloid b/A4 Protein Precursor770 (668-713), (Cys668,Gly669,Arg671)-APP770 (668-713)

CYS-GLY-LYS-ARG-AMYLOID B-PROTEIN. 1mg C220H343N63O64S2 FW: 4958.66 . Synonym: (Cys668,Gly669,Arg671)-Amyloid b/A4 Protein Precursor770 (668-713), (Cys668,Gly669,Arg671)-APP770 (668-713)

PTH (1-84) (RAT). 0.5mg C406H670N122O126S3 FW: 9372.73 . pTH

PTH (1-84) (RAT). 1mg C406H670N122O126S3 FW: 9372.73 . pTH

(D-LEU6)-LHRH (1-8) (FREE ACID). 5mg CAS: 112642-14-5 C52H72N14O12 FW: 1085.23 . Synonym: (Des-Pro-NHEt9)-Leuprolide, (Des-Pro-NHEt9)-Leuprorelin

(DES-GLY10,LEU6,PRO-NHET9)-LHRH, 1mg Impurity C of the Leuprorelin Ph. Eur. monograph. CAS: 54785-87-4 C59H84N16O12 FW: 1209.42. Synonym: (Leu6)-Leuprolide, (Leu6)-Leuprorelin.

(DES-GLY10,LEU6,PRO-NHET9)-LHRH, 5mg Impurity C of the Leuprorelin Ph. Eur. monograph. CAS: 54785-87-4 C59H84N16O12 FW: 1209.42. Synonym: (Leu6)-Leuprolide, (Leu6)-Leuprorelin.

(D-TRP6)-LHRH (2-10). 5mg CAS: 108787-46-8 C59H77N17O11 FW: 1200.37 . Synonym: (Des-Pyr1,D-Trp6)-LHRH, (Des-Pyr1)-Triptorelin

AMYLOID B-PROTEIN (1-46). 0.5mg Precursor of the secreted amyloid +-protein (1-40) and (1-42). The identification of amyloid-+-protein (1-46) led to the identification of a zeta-cleavage site between the known +- and +-cleavage sites within the transmembrane domain of amyloid-+ precursor protein (APP). CAS: 285554-31-6 C223H347N59O65S FW: 4926.63 . amyloid

AMYLOID B-PROTEIN (1-46). 1mg Precursor of the secreted amyloid +-protein (1-40) and (1-42). The identification of amyloid-+-protein (1-46) led to the identification of a zeta-cleavage site between the known +- and +-cleavage sites within the transmembrane domain of amyloid-+ precursor protein (APP). CAS: 285554-31-6 C223H347N59O65S FW: 4926.63 . amyloid

AC-ARG-CYS-MET-5-AMINOPENTANOYL-ARG. 1mg Full competitive MCH-1 receptor antagonist devoid of agonist potency for the human MCH-1 receptor even at micromolar concentrations (Kb = 3.6 nM). (Disulfide bond) CAS: 353487-64-6 C49H82N16O11S3 FW: 1167.49 . Synonym: Ac-Arg-Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys-NH2

AC-ARG-CYS-MET-5-AMINOPENTANOYL-ARG. 5mg Full competitive MCH-1 receptor antagonist devoid of agonist potency for the human MCH-1 receptor even at micromolar concentrations (Kb = 3.6 nM). (Disulfide bond) CAS: 353487-64-6 C49H82N16O11S3 FW: 1167.49 . Synonym: Ac-Arg-Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys-NH2

AC-PRO-GLY-PRO-OH. 5mg This extracellular matrix (ECM)-derived CXC receptor ligand is generated during airway inflammation. The activity of Ac-Pro-Gly-Pro-OH (AcPGP) links degradation of ECM with neutrophil recruitment in airway inflammation. AcPGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases. CAS: 292171-04-1 C14H21N3O5 FW: 311.34 . Synonym: AcPGP

AC-PRO-GLY-PRO-OH. 25mg This extracellular matrix (ECM)-derived CXC receptor ligand is generated during airway inflammation. The activity of Ac-Pro-Gly-Pro-OH (AcPGP) links degradation of ECM with neutrophil recruitment in airway inflammation. AcPGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases. CAS: 292171-04-1 C14H21N3O5 FW: 311.34 . Synonym: AcPGP

PTH (1-84) (DOG). 0.5mg C414H672N122O128S2 FW: 9470.77 . Synonym: Parathyroid Hormone (1-84) (dog), Parathyrin (1-84) (dog)

AC-GLY-ASP-TYR-SER-HIS-CYS-SER-. 0.5mg DX600, Ac-GDYSHCSPLRYYPWWKCTYPDPEGGG-amide is an ACE-2-specific peptide inhibitor with a Ki of 2.8 nM. (Disulfide bond) CAS: 478188-26-0 C141H185N35O40S2 FW: 3074.36 . Synonym: DX-600

AC-GLY-ASP-TYR-SER-HIS-CYS-SER-. 1mg DX600, Ac-GDYSHCSPLRYYPWWKCTYPDPEGGG-amide is an ACE-2-specific peptide inhibitor with a Ki of 2.8 nM. (Disulfide bond) CAS: 478188-26-0 C141H185N35O40S2 FW: 3074.36 . Synonym: DX-600

CORTISTATIN-29 (RAT). 0.5mg Antiinflammatory peptide with high homology to somatostatin. (Disulfide bond) C161H240N46O41S2 FW: 3540.09 . cortistatin

CORTISTATIN-29 (RAT). 1mg Antiinflammatory peptide with high homology to somatostatin. (Disulfide bond) C161H240N46O41S2 FW: 3540.09 . cortistatin

CORTISTATIN-29 (HUMAN). 0.5mg Cortistatin-29 (human) (CST (human)) represents an antiinflammatory, immunomodulatory factor with a potential multistep therapeutic use in the treatment of septic shock and Crohn's disease. (Disulfide bond) C149H223N47O42S3 FW: 3440.9 . cortistatin

CORTISTATIN-29 (HUMAN). 1mg Cortistatin-29 (human) (CST (human)) represents an antiinflammatory, immunomodulatory factor with a potential multistep therapeutic use in the treatment of septic shock and Crohn's disease. (Disulfide bond) C149H223N47O42S3 FW: 3440.9 . cortistatin

CATESTATIN (HUMAN). 1mg SSMKLSFRARAYGFRGPGPQL, a catecholamine release-inhibitory peptide corresponding to human chromogranin A (CHGA) 370-390. Diminished expression of catestatin might increase the risk for hypertension. In Chga-/- mice rescue of elevated blood pressure to normalcy was achieved by either exogenous replacement of catestatin or transgenic expression of human CHGA. CAS: 197151-46-5 C104H164N32O27S FW: 2326.71 . catestatin

CATESTATIN (HUMAN). 5mg SSMKLSFRARAYGFRGPGPQL, a catecholamine release-inhibitory peptide corresponding to human chromogranin A (CHGA) 370-390. Diminished expression of catestatin might increase the risk for hypertension. In Chga-/- mice rescue of elevated blood pressure to normalcy was achieved by either exogenous replacement of catestatin or transgenic expression of human CHGA. CAS: 197151-46-5 C104H164N32O27S FW: 2326.71 . catestatin

KISSPEPTIN-54 (HUMAN). 0.5mg Kisspeptin-54, an endogenous ligand of the G protein-coupled receptor GPR54, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. It stimulates LH and FSH secretion. Kisspeptin-54 may represent a versatile tool for the manipulation of the HPG axis. CAS: 374683-24-6 C258H401N79O78 FW: 5857.51 . Synonym: Metastin (human), Malignant Melanoma Metastasis-Suppressor KiSS-1 (68-121) (human), KiSS-1 (68-121) (human)

KISSPEPTIN-54 (HUMAN). 1mg Kisspeptin-54, an endogenous ligand of the G protein-coupled receptor GPR54, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. It stimulates LH and FSH secretion. Kisspeptin-54 may represent a versatile tool for the manipulation of the HPG axis. CAS: 374683-24-6 C258H401N79O78 FW: 5857.51 . Synonym: Metastin (human), Malignant Melanoma Metastasis-Suppressor KiSS-1 (68-121) (human), KiSS-1 (68-121) (human)

COMPSTATIN. 0.5mg Compstatin, ICVVQDWGHHRCT , is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3. (Disulfide bond) CAS: 206645-99-0 C66H99N23O17S2 FW: 1550.79 . compstatin

COMPSTATIN. 1mg Compstatin, ICVVQDWGHHRCT , is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3. (Disulfide bond) CAS: 206645-99-0 C66H99N23O17S2 FW: 1550.79 . compstatin

CRAMP (MOUSE). 1mg CRAMP is a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. Functional studies showed CRAMP to be a potent antibiotic against Gram-negative bacteria by inhibiting growth of a variety of bacterial strains and by permeabilizing the inner membrane of E.coli directly. CAS: 376364-36-2 C178H302N50O46 FW: 3878.67 . CRAMP

CRAMP (MOUSE). 5mg CRAMP is a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. Functional studies showed CRAMP to be a potent antibiotic against Gram-negative bacteria by inhibiting growth of a variety of bacterial strains and by permeabilizing the inner membrane of E.coli directly. CAS: 376364-36-2 C178H302N50O46 FW: 3878.67 . CRAMP

CRAMP-18 (MOUSE). 1mg CRAMP-18 (mouse) corresponds to the functional region of the antibacterial peptide CRAMP. It displayed potent antibacterial activity against several bacteria with no hemolytic activity (minimal inhibitory concentration: 12.5-50 -M). CAS: 256639-17-5 C101H171N27O24 FW: 2147.64 . CRAMP