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Guanosine 3',5'-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium. Guanosine 3'',5''-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium. (Rp-8-Br-cGMPS, sodium). Lyophilized solid. HYGROSCOPIC.

Guanosine 3',5'-cyclic Monophosphorothioate, 8-(4-Chloro-phenylthio)-, Rp-Isomer, TEA. Guanosine 3'',5''-cyclic Monophosphorothioate, 8-(4-Chloro-phenylthio)-, Rp-Isomer, TEA. (Rp-8-pCPT-cGMPS, TEA). Lyophilized solid. HYGROSCOPIC.

HBDDE 1MG - 372770-1MG

D-erythro-Sphingosine, N-Hexanoyl-. (C6 Ceramide). Waxy solid. Biologically active, cell-permeable, nonphysiological ceramide analog. Induces a dramatic arrest in the Go/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM.

Hispidin. 2mg; 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone;Yellow solid packaged under inert gas. Potent inhibitor of protein kinase Cb isoform (PKCb; IC50 = 2 mM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro. Purity: 90% by HPLC. Protect from light.

Hsp25 Kinase Inhibitor. 1mg. MAPKAP Kinase 2 Inhibitor. Lyophilized solid. A 13-residue peptide acting as inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibition is competitive with respect to the substrate peptide. Purity:=98% HPLC. Supplied as a trifluoroacetate salt. MW 1396.7.

4-Hydroxynonenal. (4-Hydroxy-2-nonenal; HNE). A major aldehydic product formed by peroxidation of [omega]-6-unsaturated fatty acids. Regarded as a specific marker of lipid peroxidation. Purity: =98% by HPLC. CAS: 75899-68-2. FW: 156.2. Supplied as a solution in ethanol. 1mg.

HNMPA-(AM)3. (Hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester; pro-drug II). Colorless oil. A cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC50 = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 mM).

Caspase-1 Inhibitor I. [IL-1[beta] converting enzyme (ICE) inhibitor I; Ac-YVAD-CHO; Ac-Tyr-Val-Ala-Asp-CHO]. Potent, specific and reversible inhibitor of caspase-1. Purity: =95% by TLC. Soluble in DMSO and water. FW: 492.5. Supplied as a trifluoroacetate salt. White solid, 1mg.

Caspase-1 Inhibitor I. [IL-1[beta] converting enzyme (ICE) inhibitor I; Ac-YVAD-CHO; Ac-Tyr-Val-Ala-Asp-CHO]. Potent, specific and reversible inhibitor of caspase-1. Purity: =95% by TLC. Soluble in DMSO and water. FW: 492.5. Supplied as a trifluoroacetate salt. White solid, 5mg.

Caspase-1 Inhibitor I, Cell Permeable. (ICE inhibitor I, cell-permeable; YVAD-CHO, cell-permeable). A cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1[beta] Converting Enzyme) and caspase-4. Purity: =95% by HPCL. Soluble in DMSO. FW: 1990.5. Lyophilized solid, 1mg.

Caspase-1 Inhibitor II. [IL-1[beta] converting enzyme (ICE) inhibitor II; Ac-YVAD-CMK; Ac-Tyr-Val-Ala-Asp-CMK]. Cell-permeable and irreversible inhibitor of caspase-1 (Ki =760pM), caspase-4. Inhibits Fas-mediated apoptosis. Purity: =95% by HPLC. Soluble in DMSO. FW: 541.0. White solid, 5mg.

Caspase-1 Inhibitor IV. (ICE Inhibitor IV; Ac-YVAD-AOM). Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-4. Purity: =98% by HPLC. Soluble in DMF and DMSO. FW: 654.7. White solid, 1mg.

JAK3 Inhibitor I. 5mg. White to off-white solid. Potent & specific inhibitor of JAK3 (Janus family kinase 3; IC50 =78mM). No effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Potent inhibitor of glioblastoma cell adhesion & migration. Purity 97% HPLC. Protect from light.

JAK3 Inhibitor II. 5mg. Pale yellow solid, pkg'd under inert gas. A potent, cell-permeable, & specific inhibitor of JAK3 (IC50 = 5.6 mM). No effect on either JAK1 or JAK2. Shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Purity: 97% by HPLC. Protect from light.

K-252a, Nocardiopsis sp.. 100ug. White solid. Cell-permeable protein kinase inhibitor-inhibits CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G & tyrosine protein kinase activity of NGF receptor gp140trk. Purity=95% HPLC. RTECS NZ0550000, CAS 97161-97-2.

KT5720. 100ug. White solid. Prepared by a chemical modification of K-252a. Potent, specific, cell-permeable inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Purity: 95% by HPLC. CAS 108068-98-0. Protect from light.

KT5720. 50ug. White solid. Prepared by a chemical modification of K-252a. Potent, specific, cell-permeable inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Purity: 95% by HPLC. CAS 108068-98-0. Protect from light.

KT5823. 100ug. White solid. Protect from light. Highly specific cell-permeable inhibitor of protein kinase G (Ki = 234 nM). Purity:98% by HPLC. CAS 126643-37-6.

KT5823. 50ug. White solid. Protect from light. Highly specific cell-permeable inhibitor of protein kinase G (Ki = 234 nM). Purity:98% by HPLC. CAS 126643-37-6.

Lactacystin, Synthetic. 200ug white solid. Soluble in DMSO or water. Molecular weight: 376.4. Cell-permeable, irreversible proteasome inhibitor. Streptomyces metabolite that acts as highly specific inhibitor of 20S proteasome. Blocks proteasome activity by targeting the catalytic b-subunit.

clasto-Lactacystin beta-Lactone. Omuralide. 100ug white solid. Soluble in DMSO; unstable in queous solution. Molecular weight: 213.2. Highly specific, cell-permeable, irreversible proteasome inhibitor. In vitro, Lactacystin acts as a precursor for clasto-lactacystin beta-lactone.

Lavendustin A. ( {5-Amino-[(N-2,5-dihydroxybenzyl)-N'' -2-hydroxybenzyl]salicylic acid; RG14355} ). Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.

LIPOXIN A4 25 UG - 437720-25UG

LY 294002. ( [2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]). Off-white solid. Cell-permeable, potent and specific phosphatidylinositol 3-kinase (Pl 3-kinase) inhibitor (IC50 = 1.4 mM) that acts on the ATP-binding site of the enzyme.

MMP-3 Inhibitor (Stromelysin-1 Inhibitor). Formula: C27H46N10O9S. Comments: HYGROSCOPIC. Inhibits the matrix metalloproteinase stromelysin-1 (MMP-3) (ICfont size=-250 = 5 mM). Soluble in H2O.

MMP Inhibitor I. White solid. Inhibitor of human matrix metalloproteinases. Inhibits interstitial and granulocyte collagenases (ICfont size=-250 = 1.0 -M), granulocyte gelatinase (ICfont size=-250 = 30 -M) and skin fibroblast stromelysin (ICfont size=-250 = 150 -M).

MG-115. 5mg colorless amorphous solid. (Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal; Z-Leu-Leu-Nva-CHO). Protect from light. Potent reversible proteasome inhibitor (Ki = 21nM and 35nM for 20S and 26S proteasome, respectively). Purity: =90% by HPLC. Soluble in DMSO. Molecular weight: 461.6.

MG-132. 1mg white solid. (Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; Z-Leu-Leu-Leu-CHO). Purity=90% by HPLC. Soluble in DMSO. CAS 133407-82-6. Molecular weight: 475.6. Potent, reversible, cell-permeable proteasome inhibitor. Blocks protein breakdown in mammalian cells, permeable strains of yeast.

MG-132. 5mg white solid. (Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; Z-Leu-Leu-Leu-CHO). Purity=90% by HPLC. Soluble in DMSO. CAS 133407-82-6. Molecular weight: 475.6. Potent, reversible, cell-permeable proteasome inhibitor. Blocks protein breakdown in mammalian cells, permeable strains of yeast.

MnTBAP. [Mn(III)tetrakis(4-benzoic acid)porphyrin chloride]. Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner against paraquat (2 mM). Purity: =95% by TLC. Soluble in aqeuous base. FW: 879.2. Brown solid, 25mg.

MnTMPyP. [Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride]. Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2-superoxide even in the presence of excess EDTA. Purity: =95% by TLC. Soluble in water. FW: 909.0. Brown solid, 25mg.

Protein Kinase C Inhibitor, EGF-R Fragment 651-658, Myristolyated. ( N-Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH). Lyophilized solid. PROTECT FROM MOISTURE. Epidermal growth-factor receptor (EGF-R) conserved sequence which is identical to v-erbB (95 - 102).

Protein Kinase C Inhibitor (19-27), Cell-Permeable, Myristoylated. ( N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH2). Lyophilized solid. PROTECT FROM MOISTURE. Pseudosubstrate sequence from protein kinase Ca (PKCa) and PKCb. N-terminal is myristoylated to allow membrane permeability.

Protein Kinase A Inhibitor Amide 14-22, Cell-Permeable, Myristoylated. ( N-Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2). Lyophilized solid. HYGROSCOPIC.

NF-kB SN50, Cell-Permeable Inhibitor Peptide. ( H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH). Lyophilized solid. HYGROSCOPIC.

NF-kB SN50M, Cell-Permeable Inactive Control Peptide. ( H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH). Lyophilized solid. HYGROSCOPIC. An inactive control for SN50 peptide (Cat. No. 481480).

NG-Nitro-L-arginine Methyl Ester, Hydrochloride. More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500nM). CAS: 51298-62-5. FW: 269.7. Purity: =99% by TLC. Soluble in water. 100mg off-white solid.

(+/-)-S-Nitroso-N-acetylpenicillamine. Nitric oxide donor which mimics actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50=130nM). CAS: 79032-48-7. FW: 220.2. Purity: =95% by HPLC. Soluble in DMSO, methanol, and ethanol. Pale green solid, 20mg.

S-Nitrosoglutathione. A utility carrier of nitric oxide. Breaks down to produce nitric oxide and glutathione at pH 7.4. Causes smooth muscle relaxation and inhibits platelet aggreration. Purity: =95% by HPLC. Soluble in water. CAS: 57564-91-7. FW: 336.3. Light pink solid, 10mg.

S-Nitrosoglutathione. A utility carrier of nitric oxide. Breaks down to produce nitric oxide and glutathione at pH 7.4. Causes smooth muscle relaxation and inhibits platelet aggregation. Purity: =95% by HPLC. Soluble in water. CAS: 57564-91-7. FW: 336.3. Light pink solid, 50mg.

ODQ. A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50=20nM). CAS: 41443-28-1. FW: 187.2. Purity: =98% by TLC. Soluble in DMSO. 10mg yellow solid.

1-Oleoyl-2-acetyl-sn-glycerol. (OAG). Neat oil. Cell-permeable diacylglycerol analog that activates Ca2+-dependent protein kinase C. Also a stimulator of secretion and aggregation in blood platelets. Purity: 95% by TLC. Soluble in DMSO. CAS 86390-77-4, M.W. 398.6. Note: 1 set = 10 x 500 mg.

1-Oleoyl-2-acetyl-sn-glycerol. (OAG). Neat oil. Cell-permeable diacylglycerol analog that activates Ca2+-dependent protein kinase C. Also a stimulator of secretion and aggregation in blood platelets. Purity: 95% by TLC. Soluble in DMSO. CAS 86390-77-4, M.W. 398.6. Note: 1 set = 10 x 500 mg.

Olomoucine. 5mg. 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine. White solid. Purity=98%. Soluble in DMSO. CAS 101622-51-9. Molecular weight: 298.3. Purine derivative. Selective inhibitor of p34(cdc2)/Cyclin B (IC50=7uM) and related kinases. Competes for the ATP binding domain of the kinase.

PACOCF3. (Palmitoyl trifluoromethyl ketone). White solid. A novel Ca2+-independent reversible inhibitor of phospholipase A2 (IC50 = 3.8 mM). May also inhibit Ca2+-dependent phospholipase A2 at much higher concentrations (IC50 = 45 mM). Purity: = 97% by TLC. Soluble in DMSO and EtOH. M.W. 308.4.

Platelet Activating Factor-16. ( [1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; PAF (C16); 1-O-palmityl-2-acetyl-sn-glycero-3-phosphocholine]). Lyophilized solid. PROTECT FROM MOISTURE. Synthetic. A potent mediator of inflammation that increases vascular permeability.

Platelet Activating Factor-16. ( [1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; PAF (C16); 1-O-palmityl-2-acetyl-sn-glycero-3-phosphocholine]). Lyophilized solid. PROTECT FROM MOISTURE. Synthetic. A potent mediator of inflammation that increases vascular permeability.

PD 98059. (2'' -Amino-3'' -methoxyflavone). Pale yellow solid. PROTECT FROM LIGHT. Selectively blocks the activity of MAP kinase kinase (MEK) by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates both in vitro and in intact cells.

PD 150606. 5mg. 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid. Off-white solid. Cell-permeable, non-competitive, selective non-peptide calpain inhibitor directed towards the calcium binding sites of calpain. High specificity for calpains relative to other proteases. Purity:=95% HPLC. MW 306.1.

PD 169316. ( [4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole]). Orange yellow solid. PROTECT FROM LIGHT. A potent and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

PD 158780. 500ug. 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine.Yellow solid. Iinhibitor of EGFR tyrosine kinase activity. Inhibits heregulin-stimulated autophosphorylation in SK-BR-3 & MDA-MB-453 breast carcinomas. Purity =95% HPLC.

DL-threo-PDMP, HCl. (1-Phenyl-2-decanoylamino-3-morpholino-1-propanol, HCl). Solid. PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.

Phloretin. (2'' ,4'' ,6'' -Trihydroxy-3-p-hydroxyphenylpropiophenone). Off-white solid. Inhibits protein kinase C. Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity.

PP2. 1mg. AG 1879. 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine. Off-white solid. Inhibitor of Src family of protein tyrosine kinases. Inhibits p56lck, p59fynT & Hck. Does not significantly affect activity of EGFR kinase, JAK2, or ZAP-70. Purity =95%.

Proteasome Inhibitor I. 1mg white solid. PSI; Z-Ile-Glu(OtBu)-Ala-Leu-CHO. Purity=90% by HPLC. Soluble in methanol. Molecular weight: 618.8. Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells.

Proteasome Inhibitor I. 5mg white solid. PSI; Z-Ile-Glu(OtBu)-Ala-Leu-CHO. Purity=90% by HPLC. Soluble in methanol. Molecular weight: 618.8. Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells.

Proteasome Inhibitor II. 1mg white lyophilized solid. Purity=95%, HPLC. Soluble: DMSO. Molecular weight: 509.7. Cell-permeable proteasome inhibitor. Inhibits chymotrypsin-like activity of pituitary multicatalytic proteinase complex. Won't inhibit MPC peptidylglutamyl-peptide hydrolyzing activity.

Proteasome Inhibitor II. 5mg white lyophilized solid. Purity=95%, HPLC. Soluble: DMSO. Molecular weight: 509.7. Cell-permeable proteasome inhibitor. Inhibits chymotrypsin-like activity of pituitary multicatalytic proteinase complex. Won't inhibit MPC peptidylglutamyl-peptide hydrolyzing activity.

Protein Kinase A Inhibitor Amide 6-22. (PKI 6-22 amide, PKA inhibitor; H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2). Lyophilized solid. HYGROSCOPIC. A potent and competitive inhibitor of PKA (Ki = 1.7 nM). Purity: = 97% by HPLC. Soluble in H2O.

Rapamycin. Antifungal and immunosuppressant. Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50=50pM). Prevents the translational activation of IGF-II. Purity: =98% by TLC. Soluble in DMSO and methanol. CAS: 53123-88-9. FW: 914.2. Yellow solid, 1mg.

Ribonuclease Inhibitor, E. coli. Liquid. In 50 mM KCl, 20 mM HEPES, 8 mM DTT, 50% glycerol. Non-competitive inhibitor that inactivates RNase by non-covalent binding.

Roscovitine. 1mg white solid. 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine. Purity=95% by HPLC. Soluble in DMSO. Molecular weight: 354.5. Selecitive inhibitor of cyclin-dependent kinases. Displays increased anti-mitotic activity at the G1/S and G2/M phases of cell cycle.

Roscovitine. 5mg white solid. 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine. Purity=95% by HPLC. Soluble in DMSO. Molecular weight: 354.5. Selecitive inhibitor of cyclin-dependent kinases. Displays increased anti-mitotic activity at the G1/S and G2/M phases of cell cycle.

Safingol. (L-threo-Dihydrosphingosine). Colorless solid. A lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC.

SB 202190. ( [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole; FHPI]). Pale yellow solid. PROTECT FROM LIGHT. A potent inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups.

SB 203580. ( [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole]). Pale yellow solid. PROTECT FROM LIGHT.

SB 202190, Hydrochloride. 1mg. 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl. Pale yellow solid. Hygroscopic. A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (VWR No. 80054-374 ). Purity: 97% by HPLC. Protect from light.

SB 203580, Hydrochloride. 1mg. 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl. Pale yellow solid, hygroscopic. A water-soluble form of the potent MAP kinase inhibitor SB 203580 (VWR No 80054-374). Purity: 95% by HPLC. Protect from light.

SB 220025. 500ug. 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole. Beige solid. Potent & specific inhibitor of human p38 MAP Kinase. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK, 500-fold over PKA, 50-fold over PKC, & 1000 over EGFR. Purity 95% HPLC.

SB 225002. 1mg. N-(2-Hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea. Yellow solid. Potent, selective, & competitive antagonist of G-protein coupled receptor CXCR2. Shows -150-fold selectivity over CXCR1. Inhibits human & rabbit neutrophil chemotaxis induced by both IL-8 & GROa. Purity:=95% HPLC.

SIN-1, HCl. Nitric oxide (NO) donor. Spontaneously decomposes to yield NO and superoxide anion radicals. Also inhibits release of plasminogen activator inhibitor (PAI) from stimulated platelets. CAS: 16142-27-1.FW: 206.7. Purity: = 98% by TLC. Soluble in DMSO, ethanol and water. 20mg white solid.

SKF-525A, Hydrochloride. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase (IC50=90uM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. CAS: 62-68-0. FW: 390. Purity: 98% by TLC. Soluble in water. 1g white solid.

Sodium Butyrate. (Butyric Acid, sodium; NaB). A physiologically produced short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Purity: =98% by titration. Soluble in water. CAS: 156-54-7. White solid, 250mg.

Sodium 4-Phenylbutyrate. (SPB; PFNa; 4PBA; 4-phenylbutyrate, Na). A novel anti-neoplastic agent and transcriptional regulator. Inducer of tumor cytostasis and differentiation. Purity: =98% by titration. Soluble in water. CAS: 1716-12-7. FW: 186.2. White to slightly yellowish solid, 100mg.

D-erythro-Sphingosine-1-phosphate. White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells.

SU1498. 5mg. (E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile. Pale yellow solid. Potent and selective inhibitor of Flk-1 kinase, a vascular endothelial growth factor (VEGF) receptor kinase. Purity:=95% by HPLC.

TELOMERASE INHIBITOR I 150 NMO - 581004-150NMOL

Tetrahydrouridine. Lyophilized solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. Potent competitive inhibitor of cytidine deaminase. Purity: 80% by TLC. Soluble in MeOH and H2O. RTECS UW5798980, CAS 18771-50-1, M.W. 248.2.

Tranilast. 10mg. N-(3',4'-Dimethoxycinnamoyl)anthranilic Acid. Pale yellow solid. Anthranilic acid analog acting as inhibitor of VEGF- & vascular permeability factor-induced angiogenesis & collagen synthesis. Purity: =95% HPLC. RTECS DG8731000, CAS 53902-12-8.

Caspase Inhibitor I. (Z-VAD-FMK; Z-Val-Ala-Asp(OMe)-CH2F). A highly specific, cell-permeable, and irreversible inhibitor of caspases including caspase-1,-3,-4, and -7. Purity: single spot by TLC. Soluble in DMSO. FW: 467.5. White solid, 1mg.

Trichostatin A, Streptomyces sp.. A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells. Purity: =98% by HPLC. Soluble in DMSO, ethanol. CAS: 58880-19-6. FW: 302.4. Lyophilized solid, 1mg.

Tyrphostin A23. ( [a-cyano-(3,4-dihydroxy)cinnamonitrile; tyrphostin A23; RG-50810]). Yellow solid. PROTECT FROM LIGHT. Protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 mM) and the GTPase activity of transducin (IC50 = 10 mM).

Tyrphostin B42. ( [a-cyano-(3,4-dihydroxy)-N-benzylcinnamide; tyrphostin B42]). Yellow solid. PROTECT FROM LIGHT. Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). JAK-2 PTK inhibitor.

Tyrphostin A9. ( [NSC 242557; 3,5-di-t-butyl-4-hydroxy-benzylidenemalononitrile; a-cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile; tyrphostin A9; RG 50872]). Off-white solid. PROTECT FROM LIGHT. Selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM).

Tyrphostin AG 126. ( [a-Cyano-(3-hydroxy-4-nitro)cinnamonitrile; tyrphostin AG 126]). Yellow solid. PROTECT FROM LIGHT. Inhibits lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-a and nitric oxide in murine peritoneal macrophages.

Tyrphostin AG 1295. (6,7-Dimethyl-2-phenylquinoxaline; tyrphostin AG 1295). Yellow solid. PROTECT FROM LIGHT. Selectively inhibits platelet-derived growth factor (PDGF) receptor kinase (IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 mM) in Swiss 3T3 cells.

Tyrphostin AG 1478. ( [4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; tyrphostin AG 1478]). Off-white solid. PROTECT FROM LIGHT.

U0126. 1mg. 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene. White solid. Inhibitor of MEK1 and MEK2. Inhibition is noncompetitive with respect to MEK substrates, ATP, and ERK.. Purity:=98% by HPLC. Unstable in solution; reconstitute just prior to use.

U0124. 1mg, packaged under inert gas. 1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene. Off-white solid. A useful negative control for MEK inhibitors U0125 (VWR #. 80054-916) and U0126 (VWR # 80054-912). Does not inhibit MEK activity even at concentrations of 100 mM. Purity: 95% by HPLC.

Xestospongin D, Xestospongia sp.. (XeD). Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM) which is less potent than XeC (Cat. No. 682160).

YC-1. A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Purity: =99% by HPLC. Soluble in DMSO and methanol. FW: 304.3. 5mg off-white to yellow solid.

Zinc (II) Protoporphyrin IX. A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. CAS: 15442-64-5. FW: 626. Purity: =95% by TLC. Soluble in DMF and pyridine. 25mg dark red solid.

Calyculin A, Discodermia calyx. A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50=0.5-1.0nM) and protein phosphatase 1 (PP1; IC50=2nM). Purity: =98% by HPLC. Soluble in DMSO and ethanol, not in water. CAS: 101932-71-2. FW: 1009.2. Lyophilized solid, 10ug.

Chlorpromazine, HCl. Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50=17uM). Acts as peripheral vasodilator. Inhibitor of lysosomal sphingomyelinase. CAS: 69-09-0. FW: 355.3. Purity: =99% by titration. Soluble in methanol, ethanol and water. 500mg white solid.

Cypermethrin. ( [(R,S)-a-Cyano-3-phenoxybenzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate]). Crystalline solid. Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels. Purity: 95% by HPLC.

Cytochalasin B, Dihydro-. White solid. PROTECT FROM LIGHT. Induces changes in cell morphology and motility with no effect on sugar transport. Used as specific marker in studies of high affinity cytochalasin binding sites unrelated to sugar transport.

Cytochalasin B, Helminthosporium dematioideum. 5mg white solid. Purity=98% by HPLC. Soluble in DMSO and ethanol. CAS 14930-96-2. Molecular weight: 479.6. Merck index: 12, 2859. Cell-permeable fungal toxin. Inhibits cytoplasmic division. Inhibits cell movement. Induces nuclear extrusion.

Cytochalasin D, Zygusporium mansonii. 1mg white solid. Purity=98% by TLC. Soluble in CHCl3. CAS 22144-77-0. M.W.: 507.6. Cell-permeable fungal toxin. 10-fold more potent than cytochalasin B in inhibiting actin filament function. Doesn't inhibit monosaccharide transport across cell membranes.

Deltamethrin. ( [(S)-a-Cyano-3-phenoxybenzyl(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate]). Crystalline solid. Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 100 pM). May also have varied effects on ion channels.

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