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Diethyl Pyrocarbonate. (DEPC; diethyl oxydiformate). Clear colorless liquid. PROTECT FROM LIGHT. Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides.

Ellipticine. (5,11-Dimethyl-6H-pyrido[4,3-b]carbazole). Bright yellow solid. A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation. Purity: = 99% by HPLC.

Emetine, Dihydrochloride. 250mg white solid. 6', 7', 10,11-Tetramethoxyemetan, 2HCl. Purity=98% by TLC. Soluble in EtOH, H2O. CAS 316-42-7. M.W.: 553.6. Hygroscopic. Principal alkaloid of ipecac, isolated from ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes.

Etoposide. (VP-16). Topoisomerase II inhibitor (IC50=59.2uM). A derivative of Podophyllotoxin that has major activity against a number of tumors. Purity: 97% by HPLC. Soluble in DMSO. CAS: 33419-42-0. FW: 588.6. White solid, 25mg.

Fumonisin B1, Fusarium moniliforme. (FB1). White solid. Inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells.

Fumonisin B2, Fusarium moniliforme. (FB2). Off-white solid. Structural analog of Fumonisin B1 (Cat. No. 344850) that has higher cytotoxicity and specific binding to primary rat hepatocytes than fumonisin B1. Is not metabolized by primary hepatocytes. Purity: = 98% by TLC. Soluble in MeOH.

Gliotoxin, Gladiocladium fimbriatum. White solid. An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes.

a-Iodoacetamide. Pale yellow solid. Purity: = 99% by HPLC. RTECS AC4200000, CAS 144-48-9, M.W. 185.0. WARNING! Toxic. LD50 of = 200 mg/kg. May be carcinogenic/teratogenic.

Okadaic Acid, Ammonium. White solid. PROTECT FROM LIGHT. Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A. Purity: 98% by TLC. Soluble in DMSO, EtOH and H2O. CAS 155716-06-6, M.W. 822.0. WARNING! Toxic. LD50 of = 200 mg/kg.

Okadaic Acid, Potassium. White solid. PROTECT FROM LIGHT. Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A. Purity: = 99% by TLC. Soluble in DMSO, EtOH and H2O. CAS 155751-72-7, M.W. 843.1. WARNING! Toxic. LD50 of = 200 mg/kg.

Okadaic Acid, Sodium. Lyophilized solid. PROTECT FROM LIGHT. Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A. Purity: = 99% by TLC. Soluble in DMSO, EtOH and H2O. M.W. 827.0. WARNING! Toxic. LD50 of = 200 mg/kg. May be carcinogenic/teratogenic.

Milrinone. ( [1,6-Dihydro-2-methyl-6-oxo-(3,4'' -bipyridine)-5-carbonitrile] ). White solid. Selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic and vasodilatory effects on the heart. Purity: = 97% by TLC. Soluble in DMSO and EtOH.

Okadaic Acid, Prorocentrum concavum. (OA). White crystalline solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties.

Okadaic Acid, Prorocentrum concavum. (OA). White crystalline solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties.

Phenylarsine Oxide. (PAO; oxophenylarsine). A membrane-permeable protein tyrosine phosphatase inhibitor (IC50=18uM). Purity: =95% by elemental analysis. Soluble in trichloromethane and DMSO. CAS: 637-03-6. FW: 168.0. White solid, 250mg.

Phorbol-12,13-dibutyrate. (PDBu). Strong irritant for mouse skin but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+-ATPase. Purity: 99% by HPLC. Soluble in DMSO. CAS: 37558-16-0. FW: 504.6. White solid, 1mg.

Phorbol-12,13-dibutyrate. (PDBu). Strong irritant for mouse skin but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+-ATPase. Purity: 99% by HPLC. Soluble in DMSO. CAS: 37558-16-0. FW: 504.6. White solid, 5mg.

4a-Phorbol-12,13-didecanoate. (4aPDD). Solid. PACKAGED UNDER INERT GAS. Inactive on mouse skin as an inflammatory and tumor-promoting agent. Used as a negative control for Phorbol-12,13-didecanoate (PDD; Cat. No. 524392) and Phorbol-12-myristate-13-acetate (PMA; Cat. No. 524400).

4A-PHORBOL-12 13-DIDEC 5MG - 524394-5MG

Phorbol-12-myristate-13-acetate. (PMA; TPA). Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Purity: =99% by HPLC. Soluble in DMSO. CAS: 16561-29-8. FW: 616.8. White solid, 10mg.

Phorbol-12-myristate-13-acetate. (PMA; TPA). Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Purity: =99% by HPLC. Soluble in DMSO. CAS: 16561-29-8. FW: 616.8. White solid, 1mg.

Phorbol-12-myristate-13-acetate. (PMA; TPA). Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Purity: =99% by HPLC. Soluble in DMSO. CAS: 16561-29-8. FW: 616.8. White solid, 25mg.

Phorbol-12-myristate-13-acetate. (PMA; TPA). Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Purity: =99% by HPLC. Soluble in DMSO. CAS: 16561-29-8. FW: 616.8. White solid, 5mg.

Quercetin, Dihydrate. (3,3',4',5,7-Pentahydroxyflavone). An inhibitor of PI 3-kinase (IC50=3.8uM) and phospholipase A2 (IC50=2uM). Purity: 98% by HPLC. Soluble in acetic acid, aqueous alkali, and DMSO. CAS: 6151-25-3. FW: 338.3. Yellow solid, 100mg.

Sodium Nitroprusside, Dihydrate. Nitric oxide donor. Reported to reduce lipid peroxidation-induced membrane damage. CAS: 13755-38-9. Purity: 99% by titration. Soluble in water. FW: 298. 100mg red crystalline solid.

Veratridine. A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+/Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels. Purity: =98% by TLC. Soluble in DMSO, ethanol. CAS: 71-62-5. FW: 673.8. White/off-white solid, 5mg.

Vinblastine Sulfate. White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Antitumor drug alkaloid. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically tau and MAP2. Depolymerizes microtubules.

Wortmannin. (KY 12420). White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) in purified preparations and cytosolic fractions (IC50 = 5 nM).

Diclofenac Sodium. ( {2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid, sodium}). White solid. Cyclooxygenase inhibitor and potent non-steroidal anti-inflammatory drug with analgesic activity. Purity: = 98% by TLC. Soluble in H2O. RTECS AG6330000, CAS 15307-79-6, M.W. 318.1. WARNING! Toxic.

Indomethacin. ( [1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid]). Off-white solid. A non-steroidal anti-inflammatory, antipyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 mM).

Diethyl Pyrocarbonate. (DEPC; diethyl oxydiformate). Clear colorless liquid. PROTECT FROM LIGHT. Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides.

Autocamtide-2 Related Inhibitory Peptide. ( [AIP; (Ala9)-autocamtide-2]; H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH). White solid. HYGROSCOPIC. Non-phosphorylatable analog of Autocamtide-2 (Cat. No.

BAY 11-7082. 10mg. (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile. Off-white crystalline solid. Anti-inflammatory agent that inhibits TNF-alpha-inducible phosphorylation of IkB-a, decreasing expression of NF-kB & of adhesion molecules. Purity: =95% HPLC.

Bisindolylmaleimide I. ( {GF 109203X; Go 6850; 2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide}). Orange solid. A highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine.

Bisindolylmaleimide I. ( {GF 109203X; Go 6850; 2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide}). Orange solid. A highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine.

Bisindolylmaleimide I, HCl. ( {2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl}). Red solid. Inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A (Ki = 2 mM) at much higher concentrations. An enhanced water-soluble form of Bisindolylmaleimide I (Cat.

Bisindolylmaleimide I, HCl. ( {2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl}). Red solid. Inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A (Ki = 2 mM) at much higher concentrations. An enhanced water-soluble form of Bisindolylmaleimide I (Cat.

Bisindolylmaleimide IV. ( [Arcyriarubin A; 2,3-bis(1H-indol-3-yl)maleimide]). Orange solid. A potent and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 mM). Purity: = 95% by HPLC. Soluble in DMSO and MeOH.

Bisindolylmaleimide V. ( [2,3-bis(1H-Indol-3-yl)-N-methylmaleimide]). Brown solid. Useful as a negative control compound for protein kinase C inhibition studies (IC50 100 mM). Purity: = 95% by HPLC. Soluble in DMSO and MeOH. CAS 113963-68-1, M.W. 341.3.

Bisindolylmaleimide V. ( [2,3-bis(1H-Indol-3-yl)-N-methylmaleimide]). Brown solid. Useful as a negative control compound for protein kinase C inhibition studies (IC50 100 mM). Purity: = 95% by HPLC. Soluble in DMSO and MeOH. CAS 113963-68-1, M.W. 341.3.

2,3-Butanedione 2-Monoxime. (BDM). White solid. An inhibitor of skeletal and cardiac muscle contraction. A chemical phosphatase which dephosphorylates acetylcholinesterase poisoned with organophosphates.

Caffeic Acid. (3,4-Dihydroxycinnamic acid). Natural dietary compound with reported anti-carcinogenic and anti-inflammatory properties. Selective, non-competitive 5-lipoxygenase inhibitor. Purity: =98% by TLC. Soluble in DMSO and ethanol. CAS: 331-39-5. FW: 180.2. Yellow crystalline solid, 500mg.

Calphostin C, Cladosporium cladosporioides. (UCN-1028c) Highly specific inhibitor of protein kinase C (IC50=50nM). Requires light for activation. Purity: =95% by HPLC. Soluble in DMSO, ethanol. FW: 790.8. Red lyophilized solid, 100ug.

Camptothecin, Camptotheca acuminata. A DNA topoisomerase I inhibitor. Possesses antileukemic and antitumor properties. Induces apoptosis of HL-60 cells and mouse thymocytes. Purity: =95% by TLC. Soluble in DMSO. CAS: 7689-03-4. FW: 348.4. Pale yellow solid, 50mg.

Carbonyl Cyanide m-Chlorophenylhydrazone. (CCCP). Yellow solid. Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times as effective as 2,4-dinitrophenol. Binds with cytochrome C oxidase with high affinity (Kd = 270 nM).

Castanospermine, Castanospermum australe. ( [(1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine]). Lyophilized solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. Plant alkaloid, that inhibits a- and b-glucosidase. Also acts as potent inhibitor of glycoprotein processing. Exhibits antiviral properties.

Cilostamide. ( [N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide; OCP 3689]). White solid. A selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM). Purity: = 98% by TLC. Soluble in DMSO. CAS 68550-75-4, M.W. 342.4.

D609, Potassium. (Tricyclodecan-9-yl-xanthogenate, potassium). Off-white solid. Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5 - 10 mM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A or phospholipase D. Purity: = 97% by TLC.

2',5'-Dideoxyadenosine. 2'',5''-Dideoxyadenosine. White solid. Cell-permeable adenylate cyclase inhibitor (IC50 = 250 mM). Agonist of intracellular adenosine binding site (P-site). Blocks positive inotropic and chronotropic effects of b-adrenergic agents. Purity: = 98% by HPLC. Soluble in DMSO.

FeTPPS. [5,10,15,20-Tetrakis(4-sulfonatophenyl)prophyrinato iron (III), chloride]. Ferric porphyrin complex that catalytically isomerizes peroxynitrite in vivo and in vitro. Purity: =95% by TLC. Soluble in water. FW: 1024.3. Brown solid, 25mg.

Fumagillin, Aspergillus fumigatus. (Fumidil B). Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Antiprotozoal agent and angiogenesis inhibitor. Active against sporozoan parasite in bees and myxozoan parasites in fish. Also acts as a selective inhibitor of endothelial cell proliferation.

b-Glycerophosphate, Disodium. (b-GP). White solid. PROTECT FROM MOISTURE. A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor. Purity: = 97% by titration. RTECS UA0600000, CAS 819-83-0, M.

Go 6976. Off-white solid. PROTECT FROM LIGHT. Inhibitor of rat brain protein kinase C (PKC; IC50 = 7.9 nM).

Go 7874, HCl. Yellow solid. PROTECT FROM LIGHT. A potent and selective inhibitor of rat brain protein kinase C (IC50 = 4 nM) versus protein kinase A (IC50 = 0.51 mM), protein kinase G (IC50 = 4.8 mM), and myosin light chain kinase (IC50 = 0.12 mM). Purity: = 97% by HPLC. Soluble in DMSO. M.W. 507.

2-Guanidinoethylmercaptosuccinic Acid. (GEMSA). White solid. HYGROSCOPIC. Potent inhibitor of a carboxypeptidase B-like processing enzyme referred to as enkephalin convertase (Ki = 8.8 nM). Ideal for use in affinity chromatography of the enzyme. Purity: = 99% by TLC. CAS 77482-44-1, M.W. 235.2.

H-7, Dihydrochloride. A broad-based, cell-permeable serine/threonine kinase inhibitor. Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Purity: =98% by TLC. Soluble in water. CAS: 108930-17-2. FW: 364.3. Lyophilized solid, 1mg.

H-8, 2HCl. ( {N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, HCl}). Lyophilized solid. Highly active inhibitor of cyclic-nucleotide-dependent protein kinases.

H-89, 2HCl. ( {N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, HCl}). Off-white solid. PACKAGED UNDER INERT GAS. A cell-permeable, selective and potent inhibitor of protein kinase A (Ki = 48.0 nM). Inhibits other serine/threonine kinases only at higher concentrations.

HA 1077, 2HCl. ( [(5-Isoquinolinesulfonyl)homopiperazine, HCl]). Lyophilized solid. A cell-permeable Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (IC50 = 1.6 mM), protein kinase G (IC50 = 1.6 mM), and myosin light chain kinase (IC50 = 36 mM). Purity: 98% by TLC.

K-252c. Off-white solid. Inhibits protein kinase A (IC50 = 25.7 mM) and protein kinase C (IC50 = 2.45 mM). Purity: 95% by HPLC. Soluble in DMSO. M.W. 311.3.

KN-62. ( {1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine}). Off-white solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. A cell-permeable selective inhibitor of rat brain CaM kinase II (Ki = 900 nM) that binds directly to the calmodulin binding site of the enzyme.

KN-93. White solid. PROTECT FROM LIGHT. Inhibits rat brain CaM kinase II (Ki = 370 nM). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effects on protein kinase A activity.

KN-93. White solid. PROTECT FROM LIGHT. Inhibits rat brain CaM kinase II (Ki = 370 nM). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effects on protein kinase A activity.

KN-92. ( {2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzyl-amine, phosphate}). White solid. PROTECT FROM LIGHT. HYGROSCOPIC. Useful as a negative control for KN-93 (Cat. No. 422708), a Ca2+/CaM kinase II inhibitor. Purity: 97% by HPLC. Soluble in DMSO and H2O. M.W. 555.0.

KN-93, Water-Soluble. 1mg. White solid. A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Purity: 95% by HPLC. Hygroscopic. Protect from light.

LOVASTATIN 25 MG - 438185-25MG

LY 83583. Competitive inhibitor of soluble guanylate cyclase (IC50=2uM). Lowers production of cGMP levels in tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. CAS: 91300-60-6. FW: 250.2. Purity: =98% by TLC. Solubility: Acetone, ethanol. 5mg dark red solid.

MCl-186. (3-Methyl-1-phenyl-2-pyrazolin-5-one; PMP). A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Purity: =98% by elemental analysis. Soluble in DMSO. CAS: 89-25-8. FW: 174.2. Cream colored solid, 500mg.

MDL-12,330A, HCl. ( [cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine, HCl]). White powder. Cell-permeable irreversible inhibitor of adenylate cyclase (IC50 = 250 mM). Purity: 98% by HPLC. Soluble in H2O (10 mg/ml). CAS 40297-09-4, M.W. 377.0.

S-Methyl-L-thiocitrulline, Dihydrochloride. Exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50=0.3nM) compared to the endothelial enzyme (IC50=5.4uM). Purity: =90% by TLC. Soluble in water. FW: 278.2. 10mg white solid.

ML-7, HCl. ( [(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl] ). Crystalline solid. PROTECT FROM LIGHT. A cell-permeable, potent and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

ML-9, HCl. ( [1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl] ). White solid. PROTECT FROM LIGHT. Cell-permeable Inhibitor of myosin light chain kinase (Ki = 3.8 mM), protein kinase A (Ki = 32 mM) and protein kinase C (Ki = 54 mM).

NF023. ( {8,8'' -[Carbonylbis(imino-3,1-phenylene)]bis(1,3,5-napthalenetrisulfonic acid), sodium }). Off-white solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A selective and direct G-protein antagonist for a-subunits of the Go/Gi group (EC50 - 300 nM).

NS 2028. Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase. Purity: =98% by HPLC. Soluble in DMSO, ethanol or trichloromethane. FW: 269. 5mg white to off-white solid.

PPACK, DiHCl. ( D-Phe-Pro-Arg chloromethylketone, HCl). Yellow-white solid. HYGROSCOPIC. Extremely potent and selective irreversible inhibitor of thrombin. Purity: 70% by HPLC. Soluble in dilute acetic acid, 10 mM HCl. CAS 142036-63-3, M.W. 524.2.

PPACK, DiHCl. ( D-Phe-Pro-Arg chloromethylketone, HCl). Yellow-white solid. HYGROSCOPIC. Extremely potent and selective irreversible inhibitor of thrombin. Purity: 70% by HPLC. Soluble in dilute acetic acid, 10 mM HCl. CAS 142036-63-3, M.W. 524.2.

Phosphoramidon, Disodium Salt. 5mg. N-(a-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na. White lyophilized solid. Inhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Purity:95% by HPLC. Effective concentration: 1-10 mM. Protect from light.

Piceatannol. (trans-3,3'' ,4,5'' -Tetrahydroxystilbene). White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A plant metabolite that preferentially inhibits the activity of p72Syk (IC50 - 10 mM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations.

Protein Kinase Ce Translocation Inhibitor Peptide. (PKCe translocation inhibitor peptide; H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH). Lyophilized solid. HYGROSCOPIC. An octapeptide that selectively inhibits the translocation of PKCe to subcellular sites.

Inhibitor Set. Serine/Threonine Kinase Inhibitor Set, Contains 250mg PKC inhibitor, Bisindolylmaleimide I ; 1mg PKA inhibitor, H-89, Dihydrochloride; 1mg PKG inhibitor, Protein Kinase G Inhibitor; 1 mg MLCK inhibitor, ML-7; 1mg CaM kinase II inhibitor

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. CAS: 5108-96-3. FW: 164.3. Purity: =98% by titration. Soluble in water. 100mg white solid.

Resveratrol. (trans-3,4',5-Trihydroxystilbene). Phenolic product found in both grape skin and wines. Has antifungal, antitumor and antioxidative properties. Specific inhibitor of cyclooxygenase-1 (ED50=15uM). Purity: =98% by TLC. Soluble in DMSO. CAS: 501-36-0. FW: 228.2. Off-white solid, 25mg.

Rolipram. ( {4-[ 3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone}). Off-white solid. Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Purity: = 98% by TLC. Soluble in DMSO.

Rottlerin. (Mallotoxin). Solid. Inhibits protein kinase C d isozyme (PKCd; IC50 = 3 - 6 mM). Also inhibits PKCa, PKCb and PKCg isoforms, but with significantly reduced potency (IC50 = 30 - 42 mM). Has reduced inhibitory activity on PKCe, PKCh, and PKCz (IC50 = 80 - 100 mM).

Ro-31-7549. 1mg. Red to reddish-orange solid. A selective protein kinase C (PKC) inhibitor (IC50=158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cg1. Purity: 98% TLC. CAS 125313-65-7.

Ro-31-8425. 1mg. Red to reddish-orange solid. A potent and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity. Purity: 98% by HPLC. CAS 131848-97-0. Protect from light.

Ro-31-8220. ( {3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide methane sulfonate}). Red solid. PROTECT FROM LIGHT. HYGROSCOPIC.

Ro-32-0432. ( [2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methylindol-3-yl)maleimide, hydrochloride]). Red solid. PROTECT FROM LIGHT. A selective cell-permeable protein kinase C inhibitor.

SKF-86002. 5mg. Off-white solid. Bicyclic imidazole cytokine-suppressive, anti-inflammatory drug (CSAID) that inhibits osmotic stress & UV-induced apoptosis by blocking p38 MAP kinase activation & lipopolysaccharide (LPS)-stimulated IL-1 TNF-a production. Purity: 95% HPLC. CAS 72873-74-6.

SQ 22536. ( [9-(Tetrahydro-2'' -furyl)adenine]). Off-white solid. Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC50 = 200 mM). Reduces PGE2-induced inhibition of O2. production. Purity: = 98% by TLC. Soluble in DMSO and H2O. CAS 17318-31-9, M.W. 205.2.

Staurosporine, Streptomyces sp.. A potent, cell-permeable, broad spectrum inhibitor of protein kinases. Inhibits CaM kinase, myosin light chain kinase, and protein kinases A, C, and G. Purity: =99% by HPLC. Soluble in DMSO and methanol. CAS: 62996-74-1. FW: 466.5. Pale yellow solid, 100ug.

Staurosporine, Streptomyces sp.. A potent, cell-permeable, broad spectrum inhibitor of protein kinases. Inhibits CaM kinase, myosin light chain kinase, and protein kinases A, C, and G. Purity: =99% by HPLC. Soluble in DMSO and methanol. CAS: 62996-74-1. FW: 466.5. Pale yellow solid, 250ug.

Swainsonine, Swainsona canescens. ( [(1S,2S,8R,8aR)-Trihydroxyindolizidine; 8ab-indolizidine-1a,2a,8b-triol]). White solid. Reversible active-site inhibitor of lysosomal a-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models.

Tamoxifen Citrate. White crystalline solid. A potent synthetic anti-estrogen. A reversible inhibitor of protein kinase C (IC50 = 10 mM). Induces apoptosis in human malignant glioma cell lines. Purity: 98% by titration. Soluble in EtOH and MeOH. RTECS KH2387000, CAS 54965-24-1, M.W. 563.7.

TMPyP4. 25mg, pkg'd under inert gas. Tetratosylate. Purple solid. Hygroscopic. Potent inhibitor of human telomerase. Binds strongly to DNA quadruplexes by stacking on G-tetrads at core of quadruplex. Fluoresces intensely in the presence of quadruplex DNA. Purity:90% TLC. Protect from light.

Vincristine Sulfate, Apocynaceae sp.. White solid. Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronucleus and delays cell cycle progression. Antineoplastic agent.

W-5, HCl. ( [N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl]). Crystalline solid. PROTECT FROM LIGHT. Calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 mM) and myosin light chain kinase (IC50 = 230 mM). Purity: 98% by NMR. Soluble in DMSO and H2O.

W-7, HCl. ( [N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl]). White solid. PROTECT FROM LIGHT. Calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 mM) and myosin light chain kinase (IC50 = 51 mM). Purity: 98% by TLC. Soluble in H2O.

W-12, HCl. ( [N-(4-Aminobutyl)-1-naphthalenesulfonamide, HCl]). Crystalline solid. PROTECT FROM LIGHT. Calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 mM) and myosin light chain kinase (IC50 = 300 mM). Purity: = 95% by HPLC. Soluble in MeOH and H2O.

W-13, HCl. ( [N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide, HCl]). Crystalline solid. PROTECT FROM LIGHT. Calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 mM) and myosin light chain kinase (IC50 = 58 mM). Purity: = 98% by HPLC. Soluble in H2O.

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