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ACA. ( [N-(p-Amylcinnamoyl)anthranilic acid]). White solid. Inhibits epinephrine-stimulated thromboxane production via inhibition of phospholipase A2 (PLA2) in human platelets. Also blocks glucose-induced insulin secretion by pancreatic b-cells. Exhibits moderate leukotriene antagonist activity.

3-Aminobenzamide. An antiproliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase. Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Purity: =97% by TLC. Soluble in DMSO, ethanol, water. CAS: 3544-24-9. White solid, 100mg.

Aurintricarboxylic Acid. (ATA). Red solid. A polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors.

Cantharidic Acid. ( {2,3-Dicarboxy-2,3-dimethyl-1,4-epoxycyclohexane; exo-1,6-dicarboxy-endo-1,6-dimethyl-7-oxabicylco[2,2,1]heptane} ). White solid. A potent inhibitor of protein phosphatase 2A (IC50 = 50 nM). Purity: 95% by TLC. Soluble in DMSO and EtOH. CAS 28874-45-5, M.W. 214.2.

Cathepsin Inhibitor I. White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1s-1), cathepsin L (k2/Ki = 3.8 x 105 M-1s-1), cathepsin S (k2/Ki = 4.2 x 104 M-1s-1) and papain (k2/Ki = 2.4 x 103 M-1s-1).

Cathepsin Inhibitor III. White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1s-1), cathepsin L (k2/Ki = 1.5 x 105 M-1s-1), cathepsin S (k2/Ki = 6.6 x 104 M-1s-1) and papain (k2/Ki = 1.0 x 103 M-1s-1).

Curcumin, Curcuma longa L.. Inhibitor of 5-lipoxygenase (IC50=8uM) and cyclooxygenase (IC50=52uM). Has antitumor and anti-inflammatory properties. CAS: 458-37-7. FW: 368.4. Soluble in acetic acid and ethanol. Purity: 85% by HPLC. 100mg orange-yellow solid.

Dantrolene, Sodium. Orange solid. A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission.

Diacylglycerol Kinase Inhibitor I. ( {R59022; 6-{2-{4-[(p-fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one}). White to off-white solid. Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism.

Diacylglycerol Kinase Inhibitor II. ( {R59949; 3-{2-[4-(bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone}). White to off-white solid. Inhibits diacylglycerol kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM).

5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole. (DRB). White solid. Potent and specific inhibitor of casein kinase II (IC50 = 6 mM). Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II.

NG,NG-Dimethyl-L-arginine, Dihydrochloride. A reversible inhibitor of nitric oxide synthase in vitro (IC50 = 2-3uM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects. Purity: 98% by TLC. Soluble in water. CAS: 65005-57-4. FW: 275.2. 25mg white solid.

NG,NG'-Dimethyl-L-arginine, Dihydrochloride. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity. Purity: single component by TLC. Soluble in water. CAS: 65005-57-4. FW: 275.2. 25mg white solid.

Emodin. (6-Methyl-1,3,8-trihydroxyanthraquinone). Orange solid. Potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 mM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 mM).

Forskolin, Coleus forskohlii. (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy-labd-14-en-11-one; colforsin). Colorless needles. Forskolin is the major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent.

Forskolin, Coleus forskohlii. (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy-labd-14-en-11-one; colforsin). Colorless needles. Forskolin is the major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent.

Forskolin, Coleus forskohlii. (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy-labd-14-en-11-one; colforsin). Colorless needles. Forskolin is the major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent.

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-g-butyryl]-, 2HCl. ( [L-85 8051; 8,13-epoxy-7b-(N-methylpiperazino-g-butyryloxy)-1a,6b,9a-trihydroxy-labd-14-en-11-one, HCl]). White solid. PROTECT FROM MOISTURE.

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-g-butyryl]-, 2HCl. ( [L-85 8051; 8,13-epoxy-7b-(N-methylpiperazino-g-butyryloxy)-1a,6b,9a-trihydroxy-labd-14-en-11-one, HCl]). White solid. PROTECT FROM MOISTURE.

NS-398. ( [N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide]). Pale yellow solid. Selective inhibitor of cyclooxygenase-2 (COX-2). In vitro, inhibits sheep placenta COX-2 (IC50 = 3.8 mM) while COX-1 activity is completely unaffected at concentrations up to 100 mM.

Trequinsin, HCl. ( [HL 725; 9,10-dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl]). Pale yellow solid. PROTECT FROM MOISTURE. Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 0.3 nM) and platelet aggregation in vitro.

3-Isobutyl-1-methylxanthine. (IBMX). White solid. A non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2 - 50 mM). Also acts as an adenosine receptor antagonist. Purity: 98% by HPLC. Soluble in DMSO, EtOH and MeOH. RTECS ZD8500000, CAS 28822-58-4, M.W. 222.2.

3-Isobutyl-1-methylxanthine. (IBMX). White solid. A non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2 - 50 mM). Also acts as an adenosine receptor antagonist. Purity: 98% by HPLC. Soluble in DMSO, EtOH and MeOH. RTECS ZD8500000, CAS 28822-58-4, M.W. 222.2.

8-Methoxymethyl-3-isobutyl-1-methylxanthine. (8-Methoxymethyl-IBMX). White solid. Selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I; IC50 = 4 mM). Purity: 98% by TLC. Soluble in DMSO and EtOH. CAS 78033-08-6, M.W. 266.3.

MK-886. ( {3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, sodium}). White solid.

Mycophenolic Acid. An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. CAS: 24280-93-1. FW: 320.4. Purity: =95% by HPLC. Soluble in ethanol and 0.1N sodium hydroxide. 100mg lyophilized solid.

NDGA, Larrea divaricata. (Nordihydroguaiaretic acid). An antioxidant and a selective lipoxygenase (LOX) inhibitor over cyclooxygenase (IC50=100uM). Purity: =90% by HPLC. Soluble in DMSO and ethanol. CAS: 500-38-9. FW: 302.4. Crystalline solid, 250mg.

5-Nitro-2-(3-phenylpropylamino)benzoic Acid. (NPPB). Yellow solid. Potent Cl- channel blocker (IC50 = 100 nM - 100 mM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 mM). Purity: = 98% by TLC. Soluble in DMSO. CAS 107254-86-4, M.W. 300.3.

Quinacrine, 2HCl. (Mepacrine). Bright yellow solid. PROTECT FROM LIGHT. Phospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 mM). Also inhibits monoamine oxidase (MAO). Purity: one major spot by TLC.

Radicicol, Diheterospora chlamydosporia. 500ug pkg'd under inert gas. Faint yellow solid. Antifungal macrocyclic lactone antibiotic acting as protein tyrosine kinase inhibitor. Inhibits p60v-src kinase activity & expression of COX-2. Purity:97% TLC. CAS 12772-57-5.

RHC-80267. ( [1,6-bis(Cyclohexyloximinocarbonylamino)hexane]). Off-white solid. Selectively inhibits DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets.

Ruthenium Red. (Ammoniated ruthenium oxychloride; RR). Red-black solid. PROTECT FROM MOISTURE. A blocker of transmembrane Ca2+ fluxes (IC50 = 7 mM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores.

Ro-20-1724. ( [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone]). White solid. Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 2 mM). Inhibits superoxide generation and arachidonic-induced platelet aggregation.

SKF-96365, Hydrochloride. Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils and endothelial cells at concentrations that do not affect internal Ca2+ release. CAS: 130495-35-1. FW: 402.9. Purity: =98% by TLC. Soluble in water. 5mg white solid.

Sodium Orthovanadate. Off-white solid. A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+/K+ ATPase, acid and alkaline phosphatases, phosphofructokinase and adenylate kinase.

Sodium Salicylate. Non-steroidal anti-inflammatory drug that interferes with TNF-induced NF-[kappa]B activation by inhibiting phosphorylation and subsequent degradation of the I[kappa]B-[alpha] protein. CAS: 54-21-7. FW: 160.1. Purity: =98% by titration. Solubility: Ethanol, water. 5g white solid.

U-73122. ( {1-[6-((17b-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione} ). Off-white solid. Inhibits agonist-induced phospholipase C activation (IC50 = 1.0 - 2.1 mM) in human platelets and neutrophils.

U-73343. ( {1-[6-((17b-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2,5-pyrrolidinedione} ). Off-white solid. Analog of U-73122 (Cat. No. 662035) that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control. Purity: = 99% by TLC.

A77 1726. 5mg. N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide. White solid. Physiologically-active metabolite of immunosuppressive drug leflunomide that exhibits antiproliferative & anti-inflammatory properties. Purity: =97% HPLC. CAS 108605-62-5.

AG 1024. 1mg, pkg'd under inert gas. 3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile. Off-white to yellow solid. A specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Purity: 98% by HPLC. Protect from light.

Cathepsin L Inhibitor II. 5mg. Z-FY-CHO. Off-white solid. Packaged under inert gas. A potent and selective inhibitor of cathepsin L. Purity: 95% by TLC. Z-Phe-Tyr-CHO.

Collagenase Inhibitor I. Z-PDLDA-NHOH. White solid. Packaged under inert gas. A potent and specific inhibitor of vertebrate collagenases with IC50 values in the micromolar range. Purity:98% by TLC. Z-Pro-D-Leu-D-Ala-NHOH.

DPQ. Potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50=40nM). Purity: =90% by HPLC. Soluble in DMSO. FW: 302.4. Off-white to light brown solid, 1mg.

Elastase Inhibitor II. 5mg. HNE Inhibitor. MeOSuc-AAPA-CMK. MSACK. White solid. Protect from moisture. A potent irreversible inhibitor of human neutrophil elastase (HNE). Inhibition results from cross-linking of catalytic residues His57 & Ser195. Purity: 98% HPLC. MeOSuc-Ala-Ala-Pro-Ala-CMK.

Elastase Inhibitor III. 5mg. HLE Inhibitor. MeOSuc-AAPV-CMK. White solid. Protect from moisture. A potent irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 mM). Protects against lung injury induced by instillation of elastase. Purity: 98% by HPLC. MeOSuc-Ala-Ala-Pro-Val-CMK

LFM-A13. 5mg. alpha-Cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide. Pale brown solid. Specific inhibitor of BrutonGs Tyrosine Kinase. Doesn't affect enzymatic act. of other protein tyrosine kinases (ie:EGFR, HCK, IRK JAK1 & JAK3 at conc.of 278mM). Purity 97% HPLC.

MMP-3 Inhibitor II. 5mg. N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic Acid. NNGH. White solid. A potent inhibitor of human MMP-3 (Ki = 130 nM). Purity:98% by TLC.

MICROCYSTIN-LW MICROC 25 UG - 475818-25UG

NF449. 10mg. 4,4',4'',4'''-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na). White solid. Potent Gsa-subunit-selective G-protein antagonist. Suppresses rate of GTPgS binding to Gsa-s-subunit but not to Gia-1-subunit. Purity:95% by HPLC.

Parthenolide, Tanacetum parthenium. 50mg. White solid. A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-a and IL-1) in LPS-stimulated macrophages. Purity: 97% TLC. CAS 20554-84-1.

PD 168393. 1mg. 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline. Yellow solid. Potent, cell-permeable, irreversible & selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity. Binds to catalytic domain of EGFR with a 1:1 stoichiometry & alkylating Cys773. Purity95% HPLC.

PD 174265. 1mg. 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline. Yellow solid. A potent, cell-permeable, reversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity. Less effective antitumor agent than PD 168393 (80059-346). Purity:97% HPLC.

Purvalanol A. 1mg. 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine. Off-white solid. A potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases. Purity: 97% by HPLC.

GAMMA-SECRETASE INHIBI 1MG - 565750-1MG

2-Chloro-2'-deoxyadenosine. (2CdA; Cladribine). A deoxyadenosine analog that displays strong antileukemic and immunosuppresive activity. Induces apoptosis in chronic lymphocytic leukemia cells. Purity: =95% by HPLC. Soluble in DMSO. CAS: 4291-63-8. White solid, 10mg.

SB 203580 IN SOLUTION 1ML - 559398-1ML

Sulindac Sulfide. (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid. Purity =98% by TLC. Soluble in DMSO and ethanol. CAS 32004-67-4. Yellow-orange solid. Molecular weight: 340.4. Harmful. May be carcinogenic/teratogenic. Inhibits Ras signaling.

2-APB. 100mg. 2-Aminoethoxydiphenylborate. White crystalline solid. Cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits its release from rat cerebellar microsomal preparations. Purity:98% by titration. RTECS ED6150000, CAS 524-95-8.

CL-387,785-1MG - 233100-1MG

Caspase Inhibitor VI. 1mg. Z-VAD-FMK. White solid. Protect from moisture. An irreversible general caspase inhibitor. For studies involving recombinant, isolated, and purified caspase enzymes. Does not require pretreatment with esterase. Purity: single spot by TLC. Z-Val-Ala-Asp-CH2F.

EHNA, Hydrochloride. 10mg. erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl. White solid. Hygroscopic. A potent inhibitor of phosphodiesterase II (PDE II)(IC50 = 800 nM). Does not inhibit other PDE isozymes (IC50 100 mM). Purity: =97% by TLC. CAS 51350-19-7.

Epoxomicin, Synthetic. 100ug off-white solid. Purity=95% by HPLC. Soluble in DMSO, methanol. MW: 554.7. Antitumor agent of microbial origin. Potent, highly specific irreversible inhibitor of chymotrypsin-like, trypsin-like and peptidylglutamyl peptide hydrolyzing activities of proteasome.

INHIBITOR GGTI-2147-250UG - 345885-250UG

GM 6001, Negative Control. 1mg. N-t-Butoxycarbonyl-L-leucyl-L-tryptophan Methylamide. Off-white solid. Protect from moisture. A useful negative control for the MMP inhibitor GM 6001 (VWR # 80109-192). Purity: =95% by TLC.

GM 6001, Negative Control. 5mg. N-t-Butoxycarbonyl-L-leucyl-L-tryptophan Methylamide. Off-white solid. Protect from moisture. A useful negative control for the MMP inhibitor GM 6001 (VWR # 80109-192). Purity: =95% by TLC.

GM 6001. 1mg. Galardin. Off-white solid. A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Purity:=95% HPLC.

GM 6001. 5mg. Galardin. Off-white solid. A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Purity:=95% HPLC.

Merbarone. 25mg. NSC-336628. 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid. Pink solid. An anticancer drug that inhibits catalytic activity of DNA topoisomerase II (topo II) w/o damaging DNA or stabilizing DNA-topo II cleavable complexes. Purity:=95% HPLC. RTECS UV7714625, CAS 97534-21-9.

Monastrol. 1mg. 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester. White solid. Cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. Purity=95% HPLC.

Monastrol. 5mg. 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester. White solid. Cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. Purity=95% HPLC.

Proteasome Inhibitor III. 100ug white solid. Purity=99% by HPLC. Soluble in DMSO. Molecular weight: 491.4. A boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (80053-194, -196) but displays much higher potency (Ki=0.03nM vs. 4nM for MG-132).

(beta) b-Glycerophosphate, Disodium Salt, Pentahydrate. 250gm. beta-GP. White solid. Protect from moisture. A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Purity: =97% by titration. RTECS UA0600000, CAS 819-83-0.

(beta) b-Glycerophosphate, Disodium Salt, Pentahydrate. 50gm. beta-GP. White solid. Protect from moisture. A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Purity: =97% by titration. RTECS UA0600000, CAS 819-83-0.

Ubiquitin Aldehyde. 50ug lyophilized solid. Purity=95% by HPLC. Molecular weight: 8500. Potent, specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Stabilizes endogenous or in vitro synthesized ubiquitin-protein conjugates.

172806-20-1. Guanosine 3-, 5--cyclic Monophosphorothioate, B-Phenyl-1, N2-etheno-8-bromo-, Rp-Isomer, Sodium Salt, Purity: G98% by HPLC, CAS number 172806-20-1, Chemical formula: C18H14BrN5O6PS.Na, Size: 1UMOL

Bufalin. 10mg. 5b, 20(22)-Bufadienolide-3b, 14-diol. White solid. Cardiotonic steroid isolated from toads of Bufo species that inhibits ouabain-sensitive Na+,K+-ATPase activity. Induces apoptosis in various human cell lines (leukemia HL-60 & U937). Purity: =98% TLC. RTECS EI2962500, CAS 465-21-4.

COLCHICINE COLCHICUM AUTUMNAL - 234115-5GM, 5 g

FLURBIPROFEN-100MG - 344079-100MG

KETOCONAZOLE-50MG - 420600-50MG

p-Aminophenylmercuric Acetate. 700mg. APMA. Yellow solid. An organomercurial agent used for the activation of latent MMPs in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch. RTECS OV5550000, CAS 6283-24-5.

(+/-)-S-Nitroso-N-acetylpenicillamine. 1set. SNAP. Pale green solid. Protect from light. Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Purity: =95% by HPLC. CAS 79032-48-7. Note: 1 set = 5 x 5 mg.

1,5-ISOQUINOLINEDIOL-5MG - 419800-5MG

APP beta-Secretase Inhibitor. 500ug. Lyophilized solid. Hygroscopic. A potent inhibitor of amyloid precursor protein (APP) beta-secretase (IC50 = 30 nM). Purity: =98% HPLC. Supplied as trifluoroacetate salt. H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine].

Alsterpaullone. 1mg. 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one. Yellowish-brown solid. Protect from light. Pkg'd under inert gas. Potent inhibitor of Cdk1/cyclin B (IC50 = 35 nM). Displays in vitro antitumor activity. Purity =95% by HPLC.

BISINDOLYLMALEIMIDE I IN SOLUT - 203293-1ML

Calmodulin Inhibitory Peptide, Control. 500ug. MLCK Control Peptide. Lyophilized solid. Hygroscopic. A control peptide for Calmodulin Inhibitory Peptide (VWR No. 80501-998). Purity: =95% HPLC. Supplied as trifluoroacetate salt.

Calmodulin Inhibitory Peptide. 500ug. MLCK Peptide. MLCKP. Lyophilized solid. Hygroscopic. A 17-residue peptide based on calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity. Purity: =95% HPLC. Supplied as a trifluoroacetate salt.

Ciglitazone. 5mg. (-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione. Tan solid. A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARg agonist (EC50 = 3 mM). Purity:=98% by TLC. RTECS XJ5813700, CAS 74772-77-3.

ETYA. 20mg. 5,8,11,14-Eicosatetraynoic Acid. Off-white solid. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Acts as Ca2+ modulator. Purity: 95% TLC. CAS 1191-85-1.

Genistin. 5mg. Genistein, 7-O-(beta)-D-Glucopyranoside. Pale yellow solid. Protect from light. Packaged under inert gas. An isoflavone glycoside found in soy-based food products. This is an inactive analog of the PTK inhibitor Genistein. Purity:=95% by HPLC. RTECS DJ3093000, CAS 529-59-9.

GO 6976 IN SOLUTION-1ML - 365253-1ML

IC261. 5mg. 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one. Yellow solid. Potene and selective inhibitor of casein kinase (CK1) that inhibits CKCK1(delta) and CK1 (epsilon) isoenzymes. Also inhibits CK1 (alpha) at increased concs. Purity =95% by HPLC. Soluble in DMSO.

Indirubin-3'-monoxime. 1mg. Dark red solid. Protect from light. Packaged under inert gas. Inhibitor of cyclin-dependent kinases. Inhibits proliferation of large range of cells by arresting them in the G2/M phase of cell cycle. Purity: single spot-TLC. C16H11N3O2.

Kenpaullone. 1mg. 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one. NSC-664704. Yellowish-brown solid. Protect from light. Packaged under inert gas. Cell-permeable cyclin-dependent kinases (Cdks) inhibitor. Inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E & Cdk5/p25. Purity:=95% HPLC.

KIFUNESINE KITASATOSPORIA KI - 422500-1MG, 1 mg

MMP Inhibitor II. 1mg. N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide. Off-white solid. Inhibitor of MMP-1 (IC50 =24 nM), MMP-3 (IC50 =18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 =2.7 nM). Purity:=95% by HPLC. Soluble in DMSO. MW 513.6. C21H27N3O8S2.

MMP-2/MMP-9 Inhibitor I. 5mg. (2R)-2-[(4-Biphenylylsulfonyl)amino]-3-phenylpropionic Acid. White solid. Package under inert gas. A potent inhibitor of MMP-2 (IC50 = 310 nM) and MMP-9 (IC50 = 240 nM). Orally active in animal models of tumor growth and metastasis. Purity: =95% HPLC.

MMP-2/MMP-9 Inhibitor II. 1mg. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide. Off-white solid. Packaged under inert gas. A potent inhibitor of MMP-2 and MMP-9. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model. Purity:=95% by HPLC.

MMP-2/MMP-9 Inhibitor III. 1mg. White lyophilized solid. Hygroscopic. Packaged under inert gas. Hydrophobic cyclic peptide acting as potent inhibitor of MMP-2 (IC50 = 10 mM). Purity:=97% by HPLC. Supplied as a trifluoroacetate salt.

MMP-9/MMP-13 Inhibitor I. 1mg. White solid. Protect from light. Packaged under inert gas. A piperazine-based potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Purity: =95% HPLC.

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