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MELITTIN-250UG - 444605-250UG

Meloxicam. 100mg. Off-white solid. Protect from light. A non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of cyclooxygenase-2 ( IC50 = 4.7 mM) relative to cyclooxygenase-1 ( IC50 = 36.6 mM). Purity: =98% HPLC. CAS 71125-38-7.

N-(N-BUTYL)DEOXYGALACTONOJIRIM - 203994-5MG

N-ACETYLNEURAMINIC ACID 2,3-D - 252926-10MG

NFAT INHIBITOR 500UG - 480402-500UG

NU1025-5MG - 493800-5MG

PD 98059 IN SOLUTION-1ML - 513001-1ML

Protein Kinase C(zeta) Pseudosubstrate Inhibitor, Myristoylated. 500ug. Lyophilized solid. A cell-permeable inhibitor of protein kinase C(zeta) isozyme. Purity: =95% by HPLC. Supplied as a trifluoroacetate salt. Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH. MW 1928.4

Pifithrin-a. 10mg. 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr. Off-white solid. Cell-permeable p53 chemical inhibitor. Reversibly inhibits p53-dependent transactivation of p53-responsive genes & blocks p53-mediated apoptosis. Purity=95% HPLC. Soluble in DMSO. MW 367.3.

Pifithrin-a. 5mg. 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr. Off-white solid. Cell-permeable p53 chemical inhibitor. Reversibly inhibits p53-dependent transactivation of p53-responsive genes & blocks p53-mediated apoptosis. Purity=95% HPLC. Soluble in DMSO. MW 367.3.

Protein Kinase C(eta) Pseudosubstrate Inhibitor, Myristoylated. 500ug. Lyophilized solid. Protect from moisture. A cell-permeable inhibitor of protein kinase C(eta) isozyme. Purity: =95% HPLC. Supplied as a trifluoroacetate salt. Soluble in water. MW 2373.9.

Protein Kinase C(theta) Pseudosubstrate Inhibitor, Myristoylated. 500ug. Lyophilized solid. Protect from moisture. A cell-permeable inhibitor of protein kinase C(theta) isozyme. Purity: =97% by HPLC. Supplied as a trifluoroacetate salt. Soluble in water. MW 2318.9.

Protein Kinase C(zeta) Pseudosubstrate Inhibitor. 500ug. Lyophilized solid. Protect form moisture. A selective and competitive inhibitor of protein kinase C(zeta) isozyme. Purity: =95% by HPLC. Supplied as a trifluoroacetate salt. Soluble in water. MW 1718.

Raf1 Kinase Inhibitor I. 1mg. 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone. Yellow solid. Potent cRAF1 kinase inhibitor. Shows =100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Purity: =97% by HPLC. Soluble in DMSO. MW 520.9.

RIBAVIRIN-10MG - 555580-10MG

SB202190 IN SOLUTION-1ML - 559397-1ML

Shikonin. 10mg. Red solid. Naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-alpha-induced and B-16 melanoma-induced angiogenesis in mice. Purity:=97% TLC. RTECS QL8000200, CAS 517-89-5. MW 288.3.

Simvastatin. 50mg. MK-733. White solid. Purity: =98% TLC. Heavy metals: =20 ppm. RTECS EK7798000, CAS 79902-63-9. Note: Product supplied in inactive form - requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.

TCPOBOP. 25mg. 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene. White solid. Protect from light. Packaged under inert gas. Most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Purity:=95% by HPLC. RTECS UT7145000, CAS 76150-91-9.

Triptolide, Tripterygium wilfordii. 1mg. PG490. White to off-white solid. Novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Purity: =98% HPLC. RTECS YK7751000, CAS 38748-32-2. MW 360.4.

TRIPTOLIDE TRIPTERGIUM WILFO - 645900-5MG

WHI-P180, Hydrochloride. 1mg. 4-(3'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, HCl. Pale yellow solid. Potent inhibitor of lgE-mediated mast cell responses to allergens in vitro & in vivo. Also inhibits cyclin-dependent kinase 2 by blocking ATP site. Purity: =95% HPLC. Soluble in DMSO. MW 297.3.

ZM 336372. 1mg. N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide. Off-white solid. Potent & specific inhibitor of protein kinase c-Raf. Inhibits c-Raf w/ ten-fold increased potency compared to B-Raf. Purity:=95% HPLC.

bpV(HOpic). 5mg. Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V). Yellow solid. Potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Purity: =90% by 51V-NMR.

bpV(bipy). 5mg. Potassium Bisperoxo(bipyridine)oxovanadate (V). Yellow to orange solid. Protect from light. Potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor phosphorylation). Activator of insulin receptor kinase (IRK). Purity: =95% by 51V-NMR.

(gamma) g-Secretase Inhibitor II. 1mg. MW167. Off-white solid. Protect from moisture. A reversible and selective peptidomimetic inhibitor of gamma-secretase (IC50 = 13 mM for Ab). Displays weak inhibitory activity against calpain II (IC50 = 100 mM in purified enzyme assay). Purity: =90% by TLC.

ADP-HPD DIHYDRATE AMMONIUM 1ST - 118415-1SET

ADP-HPD DIHYDRATE AMMONIUM - 118415-60UG

AG 538. 5mg. Tyrphostin AG 538. Solid. Protect from light. Packaged under inert gas. Potent, competitive inhibitor of IGF-1 receptor kinase. Competitive with respect to IGF-1R substrate. Also inhibits phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGR-R & Src. Purity: =95% by HPLC.

Apicidin, Fusarium sp.. 1mg. Off-white solid. Fungal metabolite and antiprotozoal agent that acts as a potent inhibitor of parasitic histone deacetylase and HeLa cell proliferation in vitro. Induces transcriptional activation of p21WAF1 in a reversible manner. Purity: =95% by HPLC.

APICIDIN FUSARIUM SP.-5MG - 178276-5MG

CAMK IINTIDE MYRISTOYLATED-1M - 208921-1MG

Calmodulin Kinase IINtide. 1mg. Off-white solid. Potent and specific inhibitor of CaMK II. Exhibits inhibitory activity across converged species, including rat brain, goldfish brain & Drosophila. Purity: =95% by HPLC. Supplied as trifluoroacetate salt.

Caspase-3/7 Inhibitor I. 1mg. 5-[(S)-(-)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin. Yellow solid. Potent reversible, non-peptide inhibitor of caspase-3 and caspase-7. Also inhibits caspase-9, displays poor inhibitory activity against caspase-1, -2, -4, -6, and -8. Purity: =98% by HPLC.

Caspase-9 Inhibitor III. 1mg. White solid. Hygroscopic. A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (-70 nM). Purity: =96% by HPLC. Supplied as a trifluoroacetate salt. Ac-Leu-Glu-His-Asp-CMK.

Drosophila Antennapedia Homeo-Domain (43-58). 1mg. DT-5. Lyophilized solid. Hygroscopic. Membrane translocation signal seq from Drosophila Antennapedia homeo-domain (43-58) reported to act as inhibitor of PKG Ia. Purity=95% by HPLC. Supplied as trifluoroacetate salt. Soluble in DMSO. MW 2246.8

Furin Inhibitor I. 1mg. Off-white solid. Protect from moisture. Peptidyl chloromethylketone that binds to catalytic site of furin & blocks its activity. High specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Purity: =90% HPLC. Supplied as trifluoroacetate salt.

Granzyme B Inhibitor IV. 1mg. Caspase-8 inhibitor III. White solid. A reversible inhibitor of granzyme B and caspase-8. Purity: =97% by HPLC. Ac-Ile-Glu-Pro-Asp-CHO. Soluble in DMSO or H2O. MW 498.5.

LY 303511. 1mg. 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one. Yellow solid. Negative control for PI 3-kinase inhibitor LY 294002. Contains single atom substitution in morpholine ring compared to LY 294002. Purity: =98% by HPLC. Soluble in DMSO. MW 306.4.

N(W)-HYDROXY-NOR-L-ARGININE D - 399275-1MG

N omega Hydroxy-nor-L-arginine, Diacetate Salt. 5mg. L-2-Amino-(4-(2'-hydroxyguanidino)butyric Acid, 2CH3CO2H. nor-NOHA, 2CH3CO2H. Off-white solid. Hygroscopic. High affinity inhibitor of arginase. Inhibits arginase from rat liver and mouse macrophages. Purity:=97% by TLC. CAS 189302-40-7.

PJ34. 1mg. Off-white solid. Protect from light. Hygroscopic. Packaged under inert gas. Cell-permeable water-soluble phenanthridinone-derivative acting as potent inhibitor of poly(ADP-ribose) polymerase. About 10,000x more potent than 3-Aminobenzamide. Purity: =98% HPLC. Soluble in water. MW 331.8.

PJ34. 5mg. Off-white solid. Protect from light. Hygroscopic. Packaged under inert gas. Cell-permeable water-soluble phenanthridinone-derivative acting as potent inhibitor of poly(ADP-ribose) polymerase. About 10,000x more potent than 3-Aminobenzamide. Purity: =98% HPLC. Soluble in water. MW 331.8.

Protein Kinase G I(alpha) Inhibitor, Cell-Permeable. 1mg. DT-3. cGMP-dependent Protein Kinase I(alpha) Inhibitor, Cell Permeable. cGPK Ia Inhibitor. White lyophilized solid. Hygroscopic. Membrane-permeable Drosophila Antennapedia homeodomain fused peptide. Purity:=95% HPLC. MW 3294.1.

PP INHIBITOR-2 HUMAN RECOMB - 539638-100UG

Tumor Necrosis Factor (alpha) Antagonist. 1mg. TNF-a (alpha) Antagonist. WP9QY. Lyophilized solid. Hygroscopic. Exocyclic peptidomimetic acting as TNF-alpha antagonist. Purity: =95% HPLC. Supplied as a trifluoroacetate salt. MW 1226.4.

beta Secretase Inhibitor II. 1mg. N-Benzyloxycarbonyl-Val-Leu-leucinal. White lyophilized solid. Cell-permeable, reversible beta-secretase inhibitor. Corresponds to b-secretase cleavage site of Swedish mutant Amyloid Precursor Protein. Purity=95% HPLC

beta Secretase Inhibitor II. 5mg. N-Benzyloxycarbonyl-Val-Leu-leucinal. White lyophilized solid. Cell-permeable, reversible beta-secretase inhibitor. Corresponds to b-secretase cleavage site of Swedish mutant Amyloid Precursor Protein. Purity=95% HPLC

G-SECRETASE INHIBITOR IV-1MG - 565761-1MG

gamma Secretase Inhibitor VI. 5mg.1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide. White solid. Potently inhibits A(beta) 42 production. Treatment of HEK293 cells with this results in (beta) Secretase-cleaved APP fragments & secreted APP(alpha). Purity: =98% HPLC.

G40-SECRETASE INHIBITOR I-1MG - 565765-1MG

KAEMPFEROL-25MG - 420345-25MG

Y-27632. 5mg. (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl. ROCK Inhibitor. Lyophilized solid. Protect from light. Packaged under inert gas. Potent, cell-permeable & selective inhibitor of Rho-associated protein kinases. Purity: =95% by HPLC. CAS 146986-50-7. MW 338.3

SU6656. 1mg. Orange solid. A potent Src family kinase inhibitor. Inhibits Src (IC50 = 280nM) as well as closely related kinases- Fyn (IC50 =170nM), Yes (IC50 =20nM) & Lyn (IC50 =130nM). Acts as a weak inhibitor of Lck (IC50 =688uM) and PDGF receptor kinase(IC50 10uM). Purity=95% HPLC. MW 371.5.

Scriptaid. 5mg. 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide. Solid. Non-toxic hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFb/Smad4) in both stable and transient receptor assays. Purity: =95% HPLC. MW 326.4.

Indirubin-3'-monoxime-5-sulphonic Acid. 1mg. Red solid. Protect from light. Packaged under inert gas. A potent inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3(beta) (GSK-3(beta); IC50 = 80 nM). Purity: =97% by HPLC. Soluble in DMSO. MW 357.3.

JUGLONE-250MG - 420120-250MG

Dicoumarol. 500mg. Bishydroxycoumarin, Dicumarol, 3,3'-Methylenebis(4-hydroxycoumarin), White solid. Quinone reductase inhibitor with anticoagulant properties. Potentiates apoptosis by blocking SAPK/JNK and NF-kB pathways. Purity: =98% by titration. RTECS GN7875000, CAS 66-76-2.

5'-DEOXY-5'-METHYLTHIOADENOSIN - 260585-50MG

AG 1478 IN SOLUTION-1MG - 658548-1MG

Akt Inhibitor. 1mg. 1L-6-Hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate. White solid. Hygroscopic. Phosphatidylinositol ether analog that potently & selectively inhibits Akt (PKB). Inhibits phosphatidylinositol 3-kinase (PI 3-K) only weakly. Purity: =95% by NMR.

ANGELI'S SALT-10MG EA0 - 176695-10MG

Apocynin. 1gm. Acetovanillone, 4-Hydroxy-3-methoxyacetophenone. Yellow solid. Protect from light. Packaged under inert gas. Cell-permeable, anti-inflammatory phenolic compoundacting as potent and selective inhibitor of NADPH oxidase. Purity:=98% by GC. RTECS AM8800000, CAS 498-02-2.

BEC, Hydrochloride. 5mg. (S)-(2-Boronoethyl)-L-cysteine, HCI). Off-white solid. Boronic acid-based arginine analog acting as slow-binding competitive transition state inhibitor of arginases I & II. Doesn't inhibit nitric oxide synthase (NOS). Purity=95% TLC. Hygroscopic. Packed under inert gas.

BOHEMINE-1MG - 203600-1MG

CL-82198-5MG EA5 - 233105-5MG

CALPAIN INHIBITOR VI-1MG - 208745-1MG

CALPAIN INHBTR VI-5MG EA5 - 208745-5MG

CASPASE-3 INHIBITOR I CELL-PE - 235427-1MG

CASPASE-3 INHIBITOR II IN SOLU - 264156-250UG

CASPASE-8 INHIBITOR II IN SOLU - 218840-250UG

Fluvastatin. 25mg. (+/-)-(3R',5S',6E)-7-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate. Light yellow solid. Synthetic HMG-CoA reductase inhibitor that acts as anti-hypercholesterolemic agent. Purity:=98% by HPLC. RTECS MJ9675050, CAS 93957-54-1. MW 411.5.

H-89 DIHYDROCHLORIDE IN SOLUT - 371962-1MG

Heat Shock Protein Inhibitor I. 5mg. N-Formyl-3,4-methylenedioxy-benzylidine-g-butyrolactam. Solid. Benzylidene lactam compound that blocks induction of heat shock proteins HSP70, HSP72 & HSP105. Blocks development of thermotolerance in a dose-dependent manner. Purity: =95% HPLC.

Hypericin. 1MG. Black solid. Polycyclic dione that has antiretroviral activity. Inhibits protein kinase C. Also known to inhibit casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor and the epidermal growth factor receptor. Purity=85% by UV. CAS 548-04-9. MW 504.5.

JNK Inhibitor I, (L)-Form, Cell-Permeable. 1mg. (L)-HIV-TAT48-57-PP-JBD20. (L)-JNKI1. c-Jun NH2-terminal kinase. SAPK Inhibitor I. White lyophilized solid. Biologically active peptide consisting of carboxyl terminal seq. derived from JNK binding protein & amino terminal peptide. Purity=97% HPLC.

JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control. 1mg. SAPK Inhibitor I. Lyophilized solid. Hygroscopic. Cell-permeable 10-aa carrier peptide derived from HIV-TAT48-57 sequence that is modified with two proline residues. Negative control for JNK Inhibitor I, (L)-Form. Purity: =97% HPLC.

K-252A NOCARDIOPSIS SP. IN SO - 420297-100UG

KN-93 IN SOLN-1MG EA2 - 422712-1MG

KT 5720 IN SOLUTION-50UG - 420323-50UG

LY 294002 IN SOLUTION-1MG - 440204-1MG

MMP-2/MMP-9 Inhibitor IV. 500ug. SB-3CT. White solid. Selective, slow-binding & mechanism-based inhibitor of human gelatinases, MMP-2, and MMP-9. Appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Purity: = 95% by HPLC.

MYELOPEROXIDASE INHIBITOR I-1G - 475944-1GM

NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control. 500ug. NBD-Binding Peptide, Cell-Permeable, Negative Control. Off-white lyophilized solid. Cell-permeable Antennapedia-NBD mutated fusion peptide analog of NEMO-Binding Domain Binding Peptide. Purity: =95% HPLC. MW 3463.

OM99-2-250UG EA0 - 496000-250UG

PP2 IN SOLUTION-1MG - 529576-1MG

Pamidronate, Disodium Salt. 10mg. 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na. White solid. Ca metabolism regulator. Inhibits bone resorption at doses devoid of detrimental effect on bone growth & mineralization. Purity=98% HPLC. RTECS SZ6525000, CAS 57248-88-1.

SB 290157. 10mg. N2-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA. Lyophilized solid. Non-peptide acting as competitive antagonist of the anaphylatoxin C3a receptor. Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Purity: =95% HPLC. Supplied as a trifluoroacetate salt.

Sirtinol. 5mg. 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide. Sir Two Inhibitor Naphthol. Solid. Cell-permeable 2-hydroxy-1-naphthaldehyde derivative acting as inhibitor of sirtuin class of deacetylase activity, with no affect on human HDAC1. Purity: =97% HPLC. MW 394.5.

Sodium Stibogluconate. 1gm. Antimony Sodium Gluconate. NaSbv. SSG. Pale yellow solid. Pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase activity by forming a stable complex. Purity:=90% by titration-dry basis (=30% Sb content). CAS 16037-91-5.

STAUROSPORINE STREPTOMYCES SP - 569396-100UG

TAPI-0. 1mg. N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide. TNF alpha Protease Inhibitor-0. White solid. Hygroscopic. Hydroxamate-based inhibitor of collagenase, gelatinase, and TACE. Purity: =98% HPLC.

TAPI-1. 1mg. N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide. TNF-alpha Protease Inhibitor-1. White solid. Structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Purity: =98% HPLC.

TAPI-2. 1mg. N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide. TNF alpha Protease Inhibitor-2. White solid. Hydroxamate-based inhibitor of MMPs & TACE. Purity=98% HPLC. MW 415.5.

Y-27632 IN SOLUTION 500UG - 688001-500UG, 500 µg

gamma Secretase Inhibitor IX. 5mg. DAPT. N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester. Lyophilized solid. Dipeptide suppressing Ab prod. by blocking gamma secretase. Prevents Ab34 generation in murine N2a cells & hAPP/hBACE-1 transfected human HEK 293 cells. Purity=95% HPLC

gamma Secretase Inhibitor X. 250ug. L-685,458. Liquid. A 1mM solution in 372ul DMSO. Cell-permeable hydroxyethylene dipeptide isostere acting as g-secretase inhibitor. Binds to presenilin & blocks Notch intracellular domain production. Purity=90% HPLC.

SPLA2-IIA INHBTR I-1MG EA5 - 525145-1MG

SERINE PROTEASE INHIBITOR COCK - 565000-1VL

SERINE PROTEASE INHIBITOR COCK - 565000-5VL

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