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RT MAB to CD8. Rat Monoclonal antibody to CD8 (CD8a molecule) Clone: YTC 182.20 Conjugation: FITC Purity: Ig fraction Tested Applications: FACS Pkg Size: 1 ml
RB PAB to GPCR G2A. Rabbit Polyclonal antibody to GPCR G2A (G protein-coupled receptor 132) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR15. Rabbit Polyclonal antibody to GPCR GPR15 (G protein-coupled receptor 15) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR19. Rabbit Polyclonal antibody to GPCR GPR19 (G protein-coupled receptor 19) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR19. Rabbit Polyclonal antibody to GPCR GPR19 (G protein-coupled receptor 19) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR27. Rabbit Polyclonal antibody to GPCR GPR27 (G protein-coupled receptor 27) Purity: Affinity purified with antigen Species Reactivity: Human Tested Applications: ICC/IF IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR44. Rabbit Polyclonal antibody to GPCR GPR44 (G protein-coupled receptor 44) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: ICC/IF IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR45. Rabbit Polyclonal antibody to GPCR GPR45 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: ICC/IF IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR85. Rabbit Polyclonal antibody to GPCR GPR85 (G protein-coupled receptor 85) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR97. Rabbit Polyclonal antibody to GPCR GPR97 (G protein-coupled receptor 97) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR LS19072. Rabbit Polyclonal antibody to GPCR LS19072 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR MCH2. Rabbit Polyclonal antibody to GPCR MCH2 (melanin-concentrating hormone receptor 2) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: ICC/IF IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR25. Rabbit Polyclonal antibody to GPCR GPR25 (G protein-coupled receptor 25) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR48. Rabbit Polyclonal antibody to GPCR GPR48 (leucine-rich repeat containing G protein-coupled receptor 4) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR61. Rabbit Polyclonal antibody to GPCR GPR61 (G protein-coupled receptor 61) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR85. Rabbit Polyclonal antibody to GPCR GPR85 (G protein-coupled receptor 85) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPRC5B. Rabbit Polyclonal antibody to GPCR GPRC5B (G protein-coupled receptor family C group 5 member B) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR LGR8. Rabbit Polyclonal antibody to GPCR LGR8 (relaxin/insulin-like family peptide receptor 2) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR MRG. Rabbit Polyclonal antibody to GPCR MRG (MAS1 oncogene-like) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR MRGX1. Rabbit Polyclonal antibody to GPCR MRGX1 (MAS-related GPR member X1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: ICC/IF IHC-P WB Pkg Size: 25 ug
RB PAB to CELSR2. Rabbit Polyclonal antibody to CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2 (flamingo homolog Drosophila)) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to CELSR3. Rabbit Polyclonal antibody to CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3 (flamingo homolog Drosophila)) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to C5R1. Rabbit Polyclonal antibody to C5R1 (complement component 5a receptor 1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: ICC/IF IHC-P Pkg Size: 25 ug
RB PAB to EMR3. Rabbit Polyclonal antibody to EMR3 (egf-like module containing mucin-like hormone receptor-like 3) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPRC1A. Rabbit Polyclonal antibody to GPRC1A Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NPFF1 RECEPtoR. Rabbit Polyclonal antibody to NPFF1 receptor (neuropeptide FF receptor 1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NTR2. Rabbit Polyclonal antibody to NTR2 (neurotensin receptor 2) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to OR10R2. Rabbit Polyclonal antibody to OR10R2 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to MU OPIOID RECEPtoR. Rabbit Polyclonal antibody to Mu Opioid receptor (opioid receptor mu 1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NR2E3. Rabbit Polyclonal antibody to NR2E3 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NR2E3. Rabbit Polyclonal antibody to NR2E3 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to PTGDR. Rabbit Polyclonal antibody to PTGDR (prostaglandin D2 receptor (DP)) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to PAR4. Rabbit Polyclonal antibody to PAR4 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to P2Y4. Rabbit Polyclonal antibody to P2Y4 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to RORB. Rabbit Polyclonal antibody to RORB (RAR-related orphan receptor B) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to RORB. Rabbit Polyclonal antibody to RORB (RAR-related orphan receptor B) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to VN1R1. Rabbit Polyclonal antibody to VN1R1 (vomeronasal 1 receptor 1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPR50. Rabbit Polyclonal antibody to GPR50 (G protein-coupled receptor 50) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPRC1B. Rabbit Polyclonal antibody to GPRC1B Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: ICC/IF IHC-P Pkg Size: 25 ug
RB PAB to NPFF2 RECEPtoR. Rabbit Polyclonal antibody to NPFF2 receptor Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to OR2A4. Rabbit Polyclonal antibody to OR2A4 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to PAR4. Rabbit Polyclonal antibody to PAR4 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to P2Y8. Rabbit Polyclonal antibody to P2Y8 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to SREB3. Rabbit Polyclonal antibody to SREB3 (G protein-coupled receptor 173) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR102. Rabbit Polyclonal antibody to GPCR GPR102 (trace amine associated receptor 8) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to VIP RECEPtoR 1. Rabbit Polyclonal antibody to VIP receptor 1 (vasoactive intestinal peptide receptor 1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to BOMBESIN RECEPtoR 3. Rabbit Polyclonal antibody to Bombesin receptor 3 (bombesin-like receptor 3) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to EBV INDUCED GENE 2. Rabbit Polyclonal antibody to EBV induced gene 2 (G protein-coupled receptor 183) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GALR1. Rabbit Polyclonal antibody to GALR1 (galanin receptor 1) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GHRHR. Rabbit Polyclonal antibody to GHRHR (growth hormone releasing hormone receptor) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GHRHR. Rabbit Polyclonal antibody to GHRHR (growth hormone releasing hormone receptor) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to LEUKOTRIENE B4 REC. Rabbit Polyclonal antibody to Leukotriene B4 receptor Purity: Immunogen affinity purified Species Reactivity: Human Rat Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to LEUKOTRIENE B4 REC 2. Rabbit Polyclonal antibody to Leukotriene B4 receptor 2 (leukotriene B4 receptor 2) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NPFF1 RECEPtoR. Rabbit Polyclonal antibody to NPFF1 receptor Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NPFF2 RECEPtoR. Rabbit Polyclonal antibody to NPFF2 receptor Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NTR1. Rabbit Polyclonal antibody to NTR1 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR10. Rabbit Polyclonal antibody to GPCR GPR10 (prolactin releasing hormone receptor) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to PNR. Rabbit Polyclonal antibody to PNR Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to EDG6. Rabbit Polyclonal antibody to EDG6 (sphingosine-1-phosphate receptor 4) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to TA3. Rabbit Polyclonal antibody to TA3 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to CCR2. Rabbit Polyclonal antibody to CCR2 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
GT PAB to KT3 TAG. Goat Polyclonal antibody to KT3 tag Purity: Immunogen affinity purified Tested Applications: ELISA ICC/IF WB Pkg Size: 100 ug
RB PAB to GLU-GLU TAG. Rabbit Polyclonal antibody to Glu-Glu tag Purity: IgG fraction Tested Applications: ELISA Pkg Size: 100 ug
RT MAB to LY-6A/E (SCA-1). Rat Monoclonal antibody to Ly-6A/E (Sca-1) (lymphocyte antigen 6 complex locus A) Clone: D7 Purity: Purified IgG Species Reactivity: Mouse Tested Applications: FACS IHC-Fr IP WB Pkg Size: 250 ug
RB PAB to GLP1R. Rabbit Polyclonal antibody to GLP1R (glucagon-like peptide 1 receptor) Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR3. Rabbit Polyclonal antibody to GPCR GPR3 (G protein-coupled receptor 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR64. Rabbit Polyclonal antibody to GPCR GPR64 (G protein-coupled receptor 64) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR64. Rabbit Polyclonal antibody to GPCR GPR64 (G protein-coupled receptor 64) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to CYSLT1. Rabbit Polyclonal antibody to CysLT1 (cysteinyl leukotriene receptor 1) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to CXCR4. Rabbit Polyclonal antibody to CXCR4 (chemokine (C-X-C motif) receptor 4) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to CCRL1. Rabbit Polyclonal antibody to CCRL1 (chemokine (C-C motif) receptor-like 1) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR4. Rabbit Polyclonal antibody to GPCR GPR4 (G protein-coupled receptor 4) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR116. Rabbit Polyclonal antibody to GPCR GPR116 (G protein-coupled receptor 116) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPR65. Rabbit Polyclonal antibody to GPR65 (G protein-coupled receptor 65) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR48. Rabbit Polyclonal antibody to GPCR GPR48 (leucine-rich repeat containing G protein-coupled receptor 4) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR7. Rabbit Polyclonal antibody to GPCR GPR7 (neuropeptides B/W receptor 1) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR7. Rabbit Polyclonal antibody to GPCR GPR7 (neuropeptides B/W receptor 1) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR1. Rabbit Polyclonal antibody to Very Large G Protein-Coupled receptor-1 Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR1. Rabbit Polyclonal antibody to Very Large G Protein-Coupled receptor-1 Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR SALPR/GPCR135. Rabbit Polyclonal antibody to GPCR SALPR/GPCR135 (relaxin/insulin-like family peptide receptor 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR SALPR/GPCR135. Rabbit Polyclonal antibody to GPCR SALPR/GPCR135 (relaxin/insulin-like family peptide receptor 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR HM74. Rabbit Polyclonal antibody to GPCR HM74 (G protein-coupled receptor 109B) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR HM74. Rabbit Polyclonal antibody to GPCR HM74 (G protein-coupled receptor 109B) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to TRACE AMINE REC 1. Rabbit Polyclonal antibody to Trace Amine receptor 1 (trace amine associated receptor 1) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR ORF4. Rabbit Polyclonal antibody to GPCR ORF4 Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to LEUKOTRIENE B4 BLT2. Rabbit Polyclonal antibody to Leukotriene B4 receptor BLT2 (leukotriene B4 receptor 2) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to ENCEPHALOPSIN. Rabbit Polyclonal antibody to Encephalopsin (opsin 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to ENCEPHALOPSIN. Rabbit Polyclonal antibody to Encephalopsin (opsin 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to PT2. Rabbit Polyclonal antibody to PTHR2 (parathyroid hormone 2 receptor) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to F2RL1. Rabbit Polyclonal antibody to F2RL1 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPRC1C. Rabbit Polyclonal antibody to GPRC1C (glutamate receptor metabotropic 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPR48. Rabbit Polyclonal antibody to GPCR GPR48 (leucine-rich repeat containing G protein-coupled receptor 4) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to VASOPRESSIN V1B REC. Rabbit Polyclonal antibody to Vasopressin V1B receptor (arginine vasopressin receptor 1B) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPRC5C. Rabbit Polyclonal antibody to GPCR GPRC5C (G protein-coupled receptor family C group 5 member C) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPCR GPRC5C. Rabbit Polyclonal antibody to GPCR GPRC5C (G protein-coupled receptor family C group 5 member C) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to EDG6. Rabbit Polyclonal antibody to EDG6 (sphingosine-1-phosphate receptor 4) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to GPRC1C. Rabbit Polyclonal antibody to Metabotropic Glutamate Receptor 3 (glutamate receptor metabotropic 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to NEUROPEPTIDE Y REC 4. Rabbit Polyclonal antibody to Neuropeptide Y receptor 4 (pancreatic polypeptide receptor 1) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to VIPR2. Rabbit Polyclonal antibody to VIPR2 (vasoactive intestinal peptide receptor 2) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
RB PAB to CCR3. Rabbit Polyclonal antibody to CCR3 (chemokine (C-C motif) receptor 3) Purity: Immunogen affinity purified. Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
Category
Ambulatory Equipment
Apparel
Appliances (Durable Goods)
Body Pressure Relief and Positioning
Clinical Laboratory
Diagnostic Instruments and Supplies
Drainage and Suction
Furnishings
Gloves
Housekeeping
Implants
Incontinence
Indicators and Signage
Instruments
IV Therapy
Needles and Syringes
Nurse's Station and Office Supplies
Nutritionals and Feeding Supplies
Orthopedic
Ostomy
other
Personal Hygiene
Pharmaceuticals
Physical Therapy
Respiratory
Services
Sterilization
Textiles
Training and Education
Urological
Utensils
Ventilators
Wound Care
Wound Closure
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